CY 208-243
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CY 208-243
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CAS No:
100999-26-6
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Formula:
C19H18N2
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Chemical Name:
CY 208-243
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Synonyms:
Indolo[4,3-ab]phenanthridine,4,6,6a,7,8,12b-hexahydro-7-methyl-,(6aR,12bR)-;Indolo[4,3-ab]phenanthridine,4,6,6a,7,8,12b-hexahydro-7-methyl-,(6aR-trans)-;(6aR,12bR)-4,6,6a,7,8,12b-Hexahydro-7-methylindolo[4,3-ab]phenanthridine;CY 208-243;Indolophenanthridine
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CAS No:
Description
CY 208-243 is a selective dopamine D1 receptor agonist which exhibits antiparkinsonian activity[1].
LSM-3788 is a member of phenanthridines.
Characteristics
19
3.60780
1.225±0.06 g/cm3(Predicted)
227-228ºC
466.5±33.0 °C(Predicted)
236ºC
1.697
Store at RT
Drug Information
Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists. (See all compounds classified as Antiparkinson Agents.)|Drugs that bind to and activate dopamine receptors. (See all compounds classified as Dopamine Agonists.)
4,6,6a,7,8,12b-hexahydro-7-methylindolo(4,3-ab)-phenanthridine
CY 208-243 Use and Manufacturing
Centrally active dopamine D 1 receptor agonist, selective over D 2 receptor sites. Stimulates adenylate cyclase in rat striatal homogenates with an EC 50 of 125 nM. Unlike SKF 38393 ((-1-Phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol hydrobromide ), it exerts anti-Parkinsonian activity in animal models.
Computed Properties
Molecular Weight:274.4
XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Exact Mass:274.146998583
Monoisotopic Mass:274.146998583
Topological Polar Surface Area:19
Heavy Atom Count:21
Complexity:408
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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