(S)-Indoprofen
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(S)-Indoprofen
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CAS No:
53086-13-8
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Formula:
C17H15NO3
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Chemical Name:
(S)-Indoprofen
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Synonyms:
Benzeneacetic acid,4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-α-methyl-,(αS)-;Benzeneacetic acid,4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-α-methyl-,(S)-;(αS)-4-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-α-methylbenzeneacetic acid;(+)-Indoprofene;(+)-Indoprofen;d-Indoprofen;S(+)-Indoprofen;Dexindoprofen;(S)-Indoprofen;Nedius
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CAS No:
Description
A drug that has analgesic and anti-inflammatory properties. Following reports of adverse reactions including reports of carcinogenicity in animal studies it was withdrawn from the market worldwide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p21)
Characteristics
57.6
3.10010
1.308g/cm3
205-207 °C
511.3ºC at 760mmHg
263ºC
1.642
LD50 in rats (mg/kg): 31.98 i.v.; 33.75 orally (Buttinoni)
D20 +48° (c = 0.05 in DMSO)
Drug Information
Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes. (See all compounds classified as Cyclooxygenase Inhibitors.)
Dexindoprofen
Computed Properties
Molecular Weight:281.30
XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:281.10519334
Monoisotopic Mass:281.10519334
Topological Polar Surface Area:57.6
Heavy Atom Count:21
Complexity:414
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes