3,5-Dichlorobenzeneacetonitrile

The crude sulfonate was dissolved in 50 mL of DMF at 0 C. and then 3 g of KCN was added. After 2 hours an additional 50 mL of DMF was added and the solution was stirred for 16 hours. The red solution was diluted with 1 L of H20 and acidified to pH 3 with 3N HCl. The aqueous solution was extracted with dichloromethane. The combined organics were washed with 3N HCl, dried with Na2SO4 and the solvents removed at reduced pressure to yield crude The crude sulfonate was dissolved in 50 mL of DMF at 0 C. and then 3 g of KCN was added. After 2 hours an additional 50 mL of DMF was added and the solution was stirred for 16 hours. The red solution was diluted with 1 L of H20 and acidified to pH 3 with 3N HCl. The aqueous solution was extracted with dichloromethane. The combined organics were washed with 3N HCl, dried with Na2SO4 and the solvents removed at reduced pressure to yield crude The crude sulfonate was dissolved in 50 mL of DMF at 0 C. and then 3 g of KCN was added. After 2 hours an additional 50 mL of DMF was added and the solution was stirred for 16 hours. The red solution was diluted with 1 L of H2 O and acidified to pH 3 with 3N HCl. The aqueous solution was extracted with dichloromethane. The combined organics were washed with 3N HCl, dried with Na2 SO4 and the solvents removed at reduced pressure to yield crude The crude sulfonate was dissolved in 50 mL of DMF at 0 C. and then 3 g of KCN was added. After 2 hours an additional 50 mL of DMF was added and the solution was stirred for 16 hours. The red solution was diluted with 1 L of H2O and acidified to pH 3 with 3N HCl. The aqueous solution was extracted with dichloromethane. The combined organics were washed with 3N HCl, dried with Na2SO4 and the solvents removed at reduced pressure to yield crude The crude sulfonate was dissolved in 50 mnL of DMF at 0 C. and then 3 g of KCN was added. After 2 hours an additional 50 mL of DMF was added and the solution was stirred for 16 hours. The red solution was diluted with 1 L of H2O and acidified to pH 3 with 3N HCl. The aqueous solution was extracted with dichloromethane. The combined organics were washed with 3N HCl, dried with Na2SO4 and the solvents removed at reduced pressure to yield crude Following the procedure of Preparation I, Parts a through i, but initially substituting ... p-bromophenyl acetonitrile, p-ethoxyphenyl acetonitrile, m-benzyloxyphenyl acetonitrile, 2, 4-diethylphenyl acetonitrile,

Molecular Weight:186.03
XLogP3:2.8
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:184.9799046
Monoisotopic Mass:184.9799046
Topological Polar Surface Area:23.8
Heavy Atom Count:11
Complexity:162
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes