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Denagliptin

Denagliptin structure

CAS No:
483369-58-0
Formula:
C20H18F3N3O
Chemical Name:
Denagliptin
Synonyms:
4-fluoro-1-(4-fluoro-(4-fluorophenyl)phenylalanyl)-2-pyrrolidinecarbonitrile;denagliptin;UNII-DOS9ZOT21L;DOS9ZOT21L;Denagliptin [INN];GW823093;GW 823093;SCHEMBL682185;CHEMBL2110666
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Denagliptin is under investigation in clinical trial NCT00387972 (Study of Denagliptin in Subjects With Type 2 Diabetes Mellitus (T2DM)).|Denagliptin is a potent, selective, orally bioavailable, fluoropyrrolidine-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity.

Denagliptin Basic Attributes

Molecular Weight：

373.3716296

Exact Mass：

373.14

UNII：

DOS9ZOT21L

DSSTox ID：

DTXSID30197492

NCI Thesaurus Code：

C76909

Characteristics

PSA：

70.1

XLogP3：

2.8

Density：

1.33±0.1 g/cm3(Predicted)

Drug Information

MeSH Entry Terms：

4-fluoro-1-(4-fluoro-(4-fluorophenyl)phenylalanyl)-2-pyrrolidinecarbonitrile

Denagliptin Use and Manufacturing

Treatment of Type 2 diabetes.

Computed Properties

Molecular Weight:373.4
XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:373.14019669
Monoisotopic Mass:373.14019669
Topological Polar Surface Area:70.1
Heavy Atom Count:27
Complexity:542
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Shaanxi Dideu Medichem Co. Ltd Contact Supplier

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Denagliptin

CAS No.: 483369-58-0

Grade: Chemical Grade

Content: 95%

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