N,N′-[Oxybis(2,1-ethanediyloxy-4,1-phenylene)]bis[acetamide]

Anthelmintic. It has been shown to be useful in fasciola infections in sheep.

Β, β'-dichloroethyl ether is prepared by the reaction of diethylene glycol with thionyl chloride under the catalysis of pyridine, which is then obtained by condensation with acetaminophen.

Resistant to liver fluke larvae. It has a significant effect on larvae of all stages before 6 weeks of age, and the worm reduction rate is almost 100%. It can be used to treat larvae of Schistosoma japonicum. The product has low toxicity. The LD50 of mice administered orally, subcutaneously and intraperitoneally was all greater than 3000mg/kg. Sheep are administered at a dose of 400-1600 mg/kg, only a few animals die, hair loss and temporary visual impairment. The product has no adverse effects on lactation, pregnancy and weak livestock, and has no effect on milk production and milk quality.

Molecular Weight:372.4
XLogP3:1.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:10
Exact Mass:372.16852187
Monoisotopic Mass:372.16852187
Topological Polar Surface Area:85.9
Heavy Atom Count:27
Complexity:404
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes