Elliptinium
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Elliptinium
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CAS No:
58337-35-2
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Formula:
C18H17N2O.C2H3O2
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Chemical Name:
Elliptinium
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Synonyms:
6H-Pyrido[4,3-b]carbazolium,9-hydroxy-2,5,11-trimethyl-,acetate (1:1);6H-Pyrido[4,3-b]carbazolium,9-hydroxy-2,5,11-trimethyl-,acetate (salt);9-Hydroxy-2-methylellipticinium acetate;NSC 264137;Ellipticine acetomethylate;2-Methyl-9-hydroxyellipticinium acetate;Celiptium;N2-Methyl-9-hydroxyellipticinium acetate;Elliptinium;Elliptinium acetate;H9M2E;NMHE;Ellipticine analog
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CAS No:
Description
Elliptinium Acetate is acetate salt of elliptinium, a derivative of the alkaloid ellipticine isolated from species of the plant family Apocynaceae, including Bleekeria vitensis, a plant with anti-cancer properties. As a topoisomerase II inhibitor and intercalating agent, elliptinium stabilizes the cleavable complex of topoisomerase II and induces DNA breakages, thereby inhibiting DNA replication and RNA and protein synthesis.
Drug Information
Agents that are capable of inserting themselves between the successive bases in DNA, thus kinking, uncoiling or otherwise deforming it and therefore preventing its proper functioning. They are used in the study of DNA. (See all compounds classified as Intercalating Agents.)|Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)
2-methyl-9-hydroxyellipticinium