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Bromadryl

Bromadryl structure

CAS No:
13977-28-1
Formula:
C18H22BrNO.ClH
Chemical Name:
Bromadryl
Synonyms:
Ethanamine,2-[1-(4-bromophenyl)-1-phenylethoxy]-N,N-dimethyl-,hydrochloride (1:1);Ethylamine,2-[(p-bromo-α-methyl-α-phenylbenzyl)oxy]-N,N-dimethyl-,hydrochloride;Ethanamine,2-[1-(4-bromophenyl)-1-phenylethoxy]-N,N-dimethyl-,hydrochloride;Mebrophenhydramine hydrochloride;Bromadryl;Mebrophenhydramine;Mebryl;Embramine hydrochloride;8060-99-9
Categories:
Organic Chemistry > Amides

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Bromadryl Basic Attributes

Molecular Weight：

384.73832

Exact Mass：

383.065

EC Number：

237-757-3

Characteristics

PSA：

12.5

XLogP3：

5.09280

Melting Point：

150-152 °C

Boiling Point：

405.8ºC at 760 mmHg

Flash Point：

199.2ºC

Vapor Pressure：

8.55E-07mmHg at 25°C

Toxicity：

Oral-Mouse LD50: 330 mg/kg; Intravenous-Mouse LD50: 80 mg/kg

Flammability characteristics：

Thermal decomposition to emit toxic nitrogen oxides, bromide and hydrochloric acid fumes

Safety Information

Storage features：

Warehouse ventilated, low temperature and dry

Precautionary statement(s)：

P261, P264, P270, P272, P280, P301+P312, P302+P352, P305+P351+P338, P310, P321, P330, P333+P313, P363, P501

Hazard Statements：

H302

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH：

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

MeSH Entry Terms：

bromadryl|11-1933

Bromadryl Use and Manufacturing

Antihistaminic.

Computed Properties

Molecular Weight:384.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:383.06515
Monoisotopic Mass:383.06515
Topological Polar Surface Area:13.7
Heavy Atom Count:22
Complexity:296
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes