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Esaxerenone

Esaxerenone structure

CAS No:
1632006-28-0
Formula:
C22H21F3N2O4S
Chemical Name:
Esaxerenone
Synonyms:
CS-2614;5G,100G,500G,cs3150;cs-3150;CS-3150 (Esaxerenone;XL-550)
Categories:
Active Pharmaceutical Ingredients > Respiratory Drugs

Description

Esaxerenone is a novel, highly potent and selective non-steroidal mineralocorticoid receptor antagonist.

Esaxerenone is under investigation in clinical trial NCT02722265 (Long-term Study of CS-3150 as Monotherapy or in Combination With Other Antihypertensive Drug in Japanese Patients With Essential Hypertension).

Esaxerenone Basic Attributes

Molecular Weight：

466.473

Exact Mass：

466.117401

UNII：

N62TGJ04A1

Characteristics

PSA：

96.8

XLogP3：

3.15

Density：

1.4±0.1 g/cm3

Boiling Point：

581.3±50.0 °C at 760 mmHg

Flash Point：

305.4±30.1 °C

Refractive Index：

1.581

Drug Information

MeSH Entry Terms：

1-(2-hydroxyethyl)-4-methyl-N-(4-(methylsulfonyl)phenyl)-5-(2-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxamide

Computed Properties

Molecular Weight:466.5
XLogP3:2.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:466.11741282
Monoisotopic Mass:466.11741282
Topological Polar Surface Area:96.8
Heavy Atom Count:32
Complexity:747
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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