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Hydroxyethyl cellulose

Hydroxyethyl cellulose structure

CAS No:
9004-62-0
Formula:
C2H6O2.xUnspecified
Chemical Name:
Hydroxyethyl cellulose
Synonyms:
Cellulose,2-hydroxyethyl ether;Cellulose hydroxyethylate;Natrosol;Cellosize WP 4400;Natrosol 250HR;Tylose H 300;Glutofix 600;Cellosize QP 4400;Cellulose hydroxyethyl ether;Natrosol 250HX;2-Hydroxyethyl cellulose;Hydroxyethyl cellulose ether;Hydroxyethyl ether cellulose;Natrosol 240JR;Natrosol 250M;Natrosol 250G;2-Hydroxyethyl cellulose ether;Cellosize QP 1500;Hercules N 100;Cellosize WP 300;Natrosol 250HHR;Cellosize WP 300H;Cellosize WP 400H;Cellosize UT 40;Natrosol 300H;Cellosize WP;Natrosol 250H;Natrosol 250;Cellosize QP 10000;Cellosize QP 15000;HEC;Cellosize 4400H16;Cellosize WPO 9H17;Cellosize QP;Tylose H 20;OETs;BL 15;HEC-Al 5000;Natrosol LR;J 164;Natrosol 250HHP;Natrosol 250H4R;Natrosol 250MH;Cellosize QP 3;Natrosol 150L;Natrosol 180L;Fuji HEC-BL 20;AW 15 (polysaccharide);Cellosize QP 30000;Natrosol 250HH;AW 15;Natrosol 180HH;Natrosol 300HH;AH 15;Cellosize WP 09;Natrosol 250LR;Natrosol 250MR;Cellosize QP 300H;Cellosize;HEC-Unicel;Natrosol 250R;Cellosize QP 52000;Fuji HEC-AL 15;HEC-Unicel QP 9;Unicel QP 52000H;Unicel QP 100MH;Unicel QP 300H;Hydroxyethyl cellulose;Fuji HEC-A 5000F;Fuji HEC-AW 15F;Tylose H 300P;Cellosize QP 300;Natrosol 250L;Natrosol GXR 250;Natrosol 250HBR;Natrosol MHR;HEC-BL 15;Natrosol 150GXR;Cellosize WP 09L;Natrosol 250J;Culminal HEC 5000PR;HEC-A 5-25CF;HEC-AH 15;Natrosol 250GR;Natrosol 250MHR;Walocel HT 6.000PFV;Telhec;Natrosol 250HHW;Cellosize TJC 500;9045-96-9;12772-61-1;53124-21-3;53124-22-4;53149-00-1;72146-24-8;81990-28-5;86168-41-4;87210-16-0;97105-13-0;142582-86-3;163648-13-3;168679-18-3;173523-80-3;189832-76-6;682809-20-7;795278-38-5;942427-43-2;950179-92-7;1029222-54-5;1239602-59-5;1421926-28-4;1422717-44-9;1613317-73-9;1984003-44-2;2284475-29-0
Categories:
Cosmetic Ingredient > Film Forming

Description

Hydroxyethyl cellulose is a non-ionic, water soluble, modified cellulose polymer used as a thickening agent for aqueous cosmetic and personal care formulations.

Hydroxyethyl cellulose is a polysaccharide derivative with gel thickening, emulsifying, bubble-forming, water-retaining and stabilizing properties. It is used as a key ingredient in many household cleaning products, lubricants and cosmetics due to its non-ionic and water-soluble nature. It is often used as an ingredient in ophthalmic pharmaceutical preparations such as artificial tear solutions and adjunct agent in topical drug formulations to facilitate the delivery of drugs with hydrophobic character.

Hydroxyethyl cellulose Basic Attributes

Molecular Weight：

154.25100

Exact Mass：

154.01200

EC Number：

618-387-5

HScode：

3912390000

Characteristics

PSA：

91.06000

XLogP3：

0.35240

Appearance：

light yellow powder

Density：

0.75 g/mL at 25ºC(lit.)

Melting Point：

140 °C

Water Solubility：

H2O: ≤5 wt. % at 20 °C

Storage Conditions：

Hydroxyethyl cellulose powder is a stable though hygroscopicmaterial.
Aqueous solutions of hydroxyethyl cellulose are relatively stableat pH 2–12 with the viscosity of solutions being largely unaffected.However, solutions are less stable below pH 5 owing to hydrolysis.At high pH, oxidation may occur.
Increasing the temperature reduces the viscosity of aqueoushydroxyethyl cellulose solutions. However, on cooling, the originalviscosity is restored. Solutions may be subjected to fre

Toxicity：

LDLo intravenous in women: 5100mg/kg/6D-

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R23/24/25

safety instructions：

26-36-45-24/25-22

RTECS Number：

FJ5958000

Marks：

Stability/Shelf Life：

Stable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

Toxicity

Toxicity Summary：

May cause chemical pneumonitis in case of inhalation and skin irritation. Animal data suggests potential alteration in female fertility.

Drug Information

Drug Indication：

For alleviating surface irritation in topical ocular administrations, such as artificial tear solutions. Hydroxyethyl cellulose is also found in topical formulations to aid in more efficient drug diffusion across the membranes.

Pharmacology：

Hydroxyethyl cellulose acts as a demulcent by relieving inflammation or irritation and dryness of eyes. It acts as one of the key ingredient and viscosity-enhancing agent to prolong corneal contact time and increase intraocular drug levels.

Mechanism of Action：

Interacts with the solid surface through hydrogen bonding to thicken and prolong the formation time of a water-retaining film. Hydroxyethyl cellulose acts as a drug carrier or microsphere to entrap other drug molecules and form a viscous gel-like dispersion, enabling drug diffusion across biological membranes.

MeSH Entry Terms：

aldiamed

Hydroxyethyl cellulose Use and Manufacturing

Methods of Manufacturing

Alkali cellulose is a natural polymer, each fiber ring containing three hydroxyl, the most active hydroxyl reaction, the formation of hydroxyethyl cellulose. The raw cotton linters or the refined pulp is soaked in the caustic soda of 30, and the press is taken out after half an hour. Crushed to an alkaline water content of 1: 2.8. Crushed alkali cellulose into the reactor, closed, vacuum, nitrogen, repeat the vacuum filling nitrogen inside the kettle to replace the air to do. Press into the pre-cooling of ethylene oxide liquid, the reactor jacket into the cooling water, control reaction 25 ℃ 2h, in hydroxyethyl cellulose crude. Crude alcohol with alcohol to wash, add acetic acid and pH 4-6, plus glyoxal cross-linked aging. And then washing with water, centrifugal dehydration, drying, milling, in hydroxyethyl cellulose. Raw material consumption (kg / t) Cotton linter or low meal 730-780 Liquid caustic (30) 2400 Ethylene oxide 900 Alcohol (95) 4500 Acetic acid 240 Glyoxal (40) 100-300.

Uses

Hydroxyethyl cellulose is generally used as a thickener, protective agent, binder, stabilizer and additives for the preparation of emulsions, gels, ointments, lotions, eye clears, suppositories and tablets, and also used as hydrophilic gelling agents. Glue, matrix materials, preparation of matrix-type sustained-release preparations, and can also be used as stabilizers in food.

Computed Properties

Molecular Weight:806.9
XLogP3:-3
Hydrogen Bond Donor Count:8
Hydrogen Bond Acceptor Count:19
Rotatable Bond Count:28
Exact Mass:806.45113000
Monoisotopic Mass:806.45113000
Topological Polar Surface Area:263
Heavy Atom Count:55
Complexity:986
Undefined Atom Stereocenter Count:18
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Glyoxal

Ethanol

Isopropanol

Nitrogen

Downstream Products

Polystyrene

Price Analysis

Make your Hydroxyethyl cellulose purchase based on the price and market insights! ECHEMI provides professional market insights with prices for you to make a better choice. Learn more on Hydroxyethyl cellulose prices .

Data: 2026-01-02
Price: 30000.00Yuan/ton
Change: 0

Drug Function and Efficacy

As a viscosity enhancer, it can improve the stability of the tear film and thus relieve dry eye symptoms

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Compound sodium chloride eye drops (Ⅱ)
Ingredients	This product is a compound preparation, containing 4.4 mg of sodium chloride, 0.8 mg of potassium chloride, and 0.7 mg of hydroxyethyl cellulose per ml. The excipients are: potassium sorbate, borax, boric acid, poloxamer, polyoxyethylene hydrogenated castor oil 60, and disodium ethylenediaminetetraacetate.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	(1) 8 ml (2) 13 ml (3) 15 ml
Manufacturer	Mentholatum (CHINA) Pharmaceuticals Limited

Povidone-iodine gel
Ingredients	Each vial of this product contains 0.25g of povidone iodine. Excipients are: hydroxyethyl cellulose, propylene glycol, glycerol, disodium hydrogen phosphate, citric acid, anhydrous sodium carbonate, sodium lauryl sulfate.
Indication	1. Do not use with alkali, alkaloids, phenol, chloral hydrate, sodium thiosulfate, starch, tannic acid. 2. If used with other drugs at the same time, drug interactions may occur. Please consult a doctor or pharmacist for details.
Specifications	5g:0.25g (containing 0.5% effective iodine)
Manufacturer	Livzon (GROUP) Pharmaceutical FACTORY

Acetaminophen extended-release tablets
Ingredients	Each tablet of this product contains 0.65g of acetaminophen, the main ingredient. The auxiliary materials are powdered cellulose, starch, hydroxyethyl cellulose, povidone, microcrystalline cellulose, pregelatinized starch, sodium carboxymethyl starch, magnesium stearate, Opadry and palm wax.
Indication	1. Long-term use of this product may cause liver damage in patients who use barbiturates (such as phenobarbital) or antispasmodics (such as belladonna). 2. Taking this product together with chloramphenicol may enhance the toxicity of the latter. 3. If used with other drugs at the same time, drug interactions may occur. Please consult a physician or pharmacist for details.
Specifications	650mg*12 tablets/box
Manufacturer	Chengdu Hengrui Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Ashland (China) Holding Co., Ltd.

China
Active
Fresenius Kabi Austria GmbH

European Union
Active
SERUMWERK BERNBURG AG

European Union
Active

See More Registered Holders

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