Calcium hydrogen phosphate dihydrate
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Calcium hydrogen phosphate dihydrate
structure -
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CAS No:
7789-77-7
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Formula:
Ca.H3O4P.2H2O
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Chemical Name:
Calcium hydrogen phosphate dihydrate
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Synonyms:
Phosphoric acid,calcium salt,hydrate (1:1:2);Phosphoric acid,calcium salt (1:1),dihydrate;Dibasic calcium phosphate dihydrate;Calcium hydrogen phosphate dihydrate;Calcium monohydrogen phosphate dihydrate;Calcium phosphate dihydrate;Monohydrogen monocalcium phosphate dihydrate;Dicalcium phosphate dihydrate;Emcompress;Emcompress Special;Calcium phosphate (CaHPO4) dihydrate;DiTab;Calcium monohydrogen orthophosphate dihydrate;Tri-Compress;Parmcompress;Calcium hydrogen phosphate (CaHPO4) hydrate (1:2);Budit 222;Bekapress D 2;Calipharm;Bonit;Emcompress Premium;12707-46-9;42617-10-7;55818-72-9;58694-36-3;84503-04-8;288297-01-8;2485018-61-7;2597038-23-6
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CAS No:
Description
white crystalline solid Dibasic calcium phosphate dihydrate is a white, odorless, tasteless powder or crystalline solid. It occurs as monoclinic crystals.
Calcium hydrogenphosphate dihydrate is a calcium salt and a hydrate.
Calcium hydrogen phosphate dihydrate Basic Attributes
172.08800
171.94500
616-542-1
O7TSZ97GEP
DTXSID90872536
28352590
Characteristics
111.69000
-0.18080
White to almost white Solid
2.31
109ºC -H2O
158ºC at 760 mmHg
1.5394
Slightly soluble in water. Soluble in dilute hydrochloric, nitric, and acetic acid. Insoluble in alcohol
Keep tightly closed.
Safety Information
NONH for all modes of transport
1
R36/37/38
S26-S36
Xi
Stable. Incompatible with acids.
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 104 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
For use as an over the counter calcium and phosphate supplement, antacid, or a source of calcium and phosphate in toothpaste.
Calcium phosphate reacts with acid in the stomach to raise the pH. In toothpaste it provides a source of calcium and phosphate ions to support remineralization of the teeth. As a supplement it provides a source of calcium and phospate, both of which are important ions in bone homeostasis.
The phosphate ions in calcium phosphate likely react with hydrochloric acid in the stomach to neutralize the pH. In toothpaste and in systemic circulation, calcium phosphate provides a source of calcium and phosphate ions to support remineralization of the teeth and bone homeostasis respectively. The increase in plasma calcium reduces calcium flux from osteocyte activity by reducing the secretion of parathyroid hormone (PTH). Calcium does this by stimulating a G-protein coupled calcium receptor on the surface of parathyroid cells. The reduction in calcium flux increases the amount of calcium deposited in bone resulting in an increase in bone mineral density. The reduction in PTH secretion also reduces the amount of vitamin D metabolized to its active form, calcidiol. Since calcidiol increases the expression of calcium dependent ATPases and transient receptor potential cation channel subfamily V member 6 (TRPV6) both of which are involved in calcium uptake from the gut, a reduction in calcidiol results in less calcium absorption. Additionally, TRPV5, the channel responsible for calcium reabsorption in the kidney, is downregulated when PTH secretion is reduced thus increasing calcium excretion via the kidneys. Another hormone, calitonin, is likely involved in the reduction of bone resorption during periods of high plasma calcium.
brushite
Calcium hydrogen phosphate dihydrate Use and Manufacturing
Dicalcium phosphate is the calcium phosphate with the formula CaHPO4. The "di" prefix in the common name arises because the formation of the HPO42– anion involves the removal of two protons from phosphoric acid, H3PO4. It is also known as dibasic calcium phosphate or calcium monohydrogen phosphate. There are three crystalline forms: a dihydrate, CaHPO4•2H2O ('DPCD'), the mineral brushite; a hemihydrate, CaHPO4•0.5H2O; and anhydrous CaHPO4, ('DCPA'), the mineral monetite. Below pH 4.8 the dihydrate and anhydrous forms of dicalcium phosphate are the most stable (insoluble) of the calcium phosphates. Dicalcium phosphate is used as a food additive, it is found in some toothpastes as a polishing agent and is a biomaterial. In the dihydrate (brushite) form it is found in some kidney stones and in dental calculi.
Cosmetics -> Abrasive
Computed Properties
Molecular Weight:172.09
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Exact Mass:171.9449657
Monoisotopic Mass:171.9449657
Topological Polar Surface Area:85.4
Heavy Atom Count:8
Complexity:46.5
Covalently-Bonded Unit Count:4
Compound Is Canonicalized:Yes
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Calcium hydrogen phosphate dihydrate
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