Sodium thiosulfate

158.097

157.908417

231-867-5

L0IYT1O31N

1138

DTXSID9042417

POWDER|COLORLESS MONOCLINIC CRYSTALS

28323000

104

-4.35 (calculated)

colourless crystals or white powder

1.667 g/cm³

48 °C

100°C

INDEX OF REFRACTION: 1.489 ALPHA, 1.508 BETA, 1.536 GAMMA; OPTIC SIGN +

Solubility in water, g/100ml at 20°C: 20.9

2-8ºC

Vapour pressure at 20°C: negligible

Non-toxic

WHEN SODIUM NITRITE & THIOSULFATE MIXT WAS HEATED TO EVAPORATE TO DRYNESS, VIOLENT EXPLOSION OCCURRED.

NONH for all modes of transport

1

R36/37/38

S24/25-S23-S36-S26

XN6476000

Xi:Irritant

Separated from strong oxidants.

Stable. Incompatible with strong acids, strong oxidizing agents, iodine, mercury.

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

H315

121.101; LIMITATIONS: GRAS, SEQUESTRANT IN SALT UP TO 0.1%

Not combustible. Gives off irritating or toxic fumes (or gases) in a fire. Risk of explosion on contact with oxidizing agents.

|Warning|H315 (85.89%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 2915 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

In case of fire in the surroundings, use appropriate extinguishing media.

DRY TRITURATION WITH OXIDIZING AGENTS SUCH AS POTASSIUM CHLORATE, POTASSIUM PERMANGANATE, OR NITRATE MAY CAUSE EXPLOSION.|WHEN SODIUM NITRITE & THIOSULFATE MIXT WAS HEATED TO EVAPORATE TO DRYNESS, VIOLENT EXPLOSION OCCURRED.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers.

Separated from strong oxidants.

A nuisance-causing concentration of airborne particles can be reached quickly when dispersed.

NO contact with oxidizing agents.

Avoid inhalation of dust.

Wear safety goggles.

Prevention of platinum-induced ototoxic hearing loss

Antidotes; Antitubercular Agents; Antioxidants; Chelating Agents|SODIUM THIOSULFATE, USP, IS INTENDED FOR PARENTERAL USE IN TREATMENT OF CYANIDE POISONING, BUT IT MAY BE APPLIED TO SKIN IN VARIOUS FORMS. CUTANEOUS INFECTIONS CAUSED BY STAPH AUREUS & STAPH EPIDERMIDIS MAY RESPOND TO CONCN AS LOW AS 0.5%. CONCN OF 2-8%...USED TO TREAT ACNE; THEY ARE ALSO ANTIFUNGAL.|/SODIUM THIOSULFATE USP/...IS USEFUL IN TOPICAL TREATMENT OF TINEA VERSICOLOR, TINEA CRURIS, & POSSIBLY MOST OTHER DERMATOPHYTOSES.|MEDICATION (VET): IN CYANIDE POISONING; HAS BEEN USED...EXTERNALLY IN RINGWORM, MANGE.|For more Therapeutic Uses (Complete) data for SODIUM THIOSULFATE (6 total), please visit the HSDB record page.

PHYSICALLY INCOMPATIBLE WITH IV CALCIUM SALTS.

3(?). 3= MODERATELY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 0.5-5 G/KG, BETWEEN 1 OZ & 1 PINT (OR 1 LB) FOR 70 KG PERSON (150 LB).

Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. (See all compounds classified as Antioxidants.)|Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy. (See all compounds classified as Antitubercular Agents.)|Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS. (See all compounds classified as Chelating Agents.)|Agents counteracting or neutralizing the action of POISONS. (See all compounds classified as Antidotes.)

POORLY ABSORBED FROM BOWEL. ... THIOSULFATE ION DISTRIBUTES ITSELF IN EXTRACELLULAR FLUID.

/ANTIFUNGAL ACTION OF SODIUM THIOSULFATE, USP,/...IS PROBABLY ATTRIBUTABLE TO SLOW RELEASE OF COLLOIDAL SULFUR.|IN CYANIDE POISONING, SODIUM NITRITE IS INJECTED IV...TO PRODUCE METHEMOGLOBIN WHICH COMBINES WITH...CYANIDE ION & RENDERS IT TEMPORARILY INACTIVE IN FORM OF CYANMETHEMOGLOBIN. SODIUM THIOSULFATE /USP/ IS THEN INJECTED IV TO FORM NONTOXIC THIOCYANATE.|THIOSULFATE SERVES AS SUBSTRATE FOR ENZYME RHODANESE, WHICH MEDIATES CONVERSION OF CYANIDE TO MUCH LESS TOXIC THIOCYANATE, WHICH IS EXCRETED IN URINE.

Fresh air, rest.

Rinse and then wash skin with water and soap.

Rinse with plenty of water for several minutes (remove contact lenses if easily possible).

REMARKABLY INERT IN VIVO, EXCEPT FOR OSMOTIC DISTURBANCES. ... ACTS AS OSMOTIC CATHARTIC.

pentahydrate of sodium thiosulfate

Redness.

90% FOR PHOTOGRAPHY; 5% FOR LEATHER TANNING; 5% FOR CHEMICALS AND MISC APPLICATIONS (1969)|Photographic, 25%; Anitchlor: Paper-25%, Water-20%, Chlor/Alkali-10%; Oil Well Drilling Muds, 10%; Tetramethyl Lead Manufacture, 5%; Other, 5% (1985)

Grades: Technical; Crystals; granulated; photographic; C.P.; U.S.P.; F.C.C.

All other basic inorganic chemical manufacturing|Thiosulfuric acid (H2S2O3), sodium salt (1:2): ACTIVE|INCOMP: ACIDS DECOMP /IT/...WITH...PPTN /OF SULFUR & LIBERATION OF SO2/. IN ACID SOLN.../IT/ HAS REDUCING POWERS, & IS THEREFORE INCOMPATIBLE WITH OXIDIZING AGENTS. LEAD, SILVER & MERCUROUS SALTS PPT AS THIOSULFATES. SILVER HALIDES ARE MADE SOL BY.../IT/. BISMUTH SUBNITRATE IS PARTIALLY CONVERTED TO METALLIC BISMUTH.|SODIUM THIOSULFATE IS ONE OF INGREDIENTS WHICH MAY BE FOUND IN CHEMISTRY SETS. /FROM TABLE/

EPA Safer Chemical Functional Use Classes -> Processing Aids and Additives|Safer Chemical Classes -> Green half-circle - The chemical is expected to be of low concern|Human drugs -> Rare disease (orphan)|Human Drugs -> EU pediatric investigation plans|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Cosmetics -> Reducing

Food Additives -> ANTIOXIDANT; PRESERVATIVE; SEQUESTRANT;