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Trehalose

Trehalose structure

CAS No:
99-20-7
Formula:
C12H22O11
Chemical Name:
Trehalose
Synonyms:
α-D-Glucopyranoside,α-D-glucopyranosyl;Trehalose;α-D-Glucopyranosyl α-D-glucopyranoside;Ergot sugar;Mycose;Natural trehalose;α,α-Trehalose;α-D-Trehalose;D-(+)-Trehalose;α-Trehalose;D-Trehalose;α,α′-D-Trehalose;Trehaose;Treha;NSC 2093;O-D-Glucopyranosyl-(1→1)-D-glucopyranoside;Trehalose P;Thealoz;Cabaletta;Trehalose 100PH;Tremalose;229966-89-6;1898191-27-9
Categories:
Cosmetic Ingredient > Humectant

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Description

D-(+)-Trehalose, isolated from Saccharomyces cerevisiae, can be used as a food ingredient and pharmaceutical excipient.

DryPowder

Trehalose Basic Attributes

Molecular Weight：

342.29600

Exact Mass：

342.30

EC Number：

202-739-6

NSC Number：

2093

HScode：

2940000000

Characteristics

PSA：

189.53000

XLogP3：

-4.2

Appearance：

white to off-white crystalline powder

Density：

1.53 g/cm³

Melting Point：

203 °C

Boiling Point：

675.4ºC at 760 mmHg

Flash Point：

362.3ºC

Refractive Index：

197 ° (C=7, H2O)

Water Solubility：

Soluble in water.

Storage Conditions：

Trehalose is a relatively stable material. At 60°C for 5 hours it loses not more than 1.5% w/w of water (the dihydrate water of crystallization is retained). Open stored powder may liquefy at high relative humidity (≥90%).
Trehalose should be stored in a cool, dry place in a well-sealed container.

Collision Cross Section：

179.27 Å² [M-H]- [CCS Type: DT, Method: stepped-field]

Safety Information

hazard class code：

R38

safety instructions：

S24/25

Marks：

Trehalose Use and Manufacturing

Uses

Trehalose, also known as mycose or tremalose, is a natural alpha-linked disaccharide formed by an α,α-1,1-glucoside bond between two α-glucose units. In 1832, H.A.L. Wiggers discovered trehalose in an ergot of rye, and in 1859 Marcellin Berthelot isolated it from trehala manna, a substance made by weevils, and named it trehalose. It can be synthesised by bacteria, fungi, plants, and invertebrate animals. It is implicated in anhydrobiosis — the ability of plants and animals to withstand prolonged periods of desiccation. It has high water retention capabilities, and is used in food and cosmetics. The sugar is thought to form a gel phase as cells dehydrate, which prevents disruption of internal cell organelles, by effectively splinting them in position. Rehydration then allows normal cellular activity to be resumed without the major, lethal damage that would normally follow a dehydration/rehydration cycle. Trehalose is not an antioxidant, because it is a non-reducing sugar and does not contain nucleophilic groups in its molecule. However, it was reported to have antioxidant effects.Extracting trehalose was once a difficult and costly process, but circa the year 2000, the Hayashibara company (Okayama, Japan) confirmed an inexpensive extraction technology from starch for mass production. Trehalose is used in a broad spectrum of applications.

Processing aids, not otherwise listed

Agricultural products (non-pesticidal)

Manufacturing Info：

Pesticide, fertilizer, and other agricultural chemical manufacturing|.alpha.-D-Glucopyranoside, .alpha.-D-glucopyranosyl: ACTIVE

Computed Properties

Molecular Weight:342.30
XLogP3:-4.2
Hydrogen Bond Donor Count:8
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:4
Exact Mass:342.11621151
Monoisotopic Mass:342.11621151
Topological Polar Surface Area:190
Heavy Atom Count:23
Complexity:348
Undefined Atom Stereocenter Count:10
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Glucose

Starch

Price Analysis

Make your Trehalose purchase based on the price and market insights! ECHEMI provides professional market insights with prices for you to make a better choice. Learn more on Trehalose prices .

Drug Function and Efficacy

Protects skin cells from dehydration and environmental damage, stabilizes cellular structure

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

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Registered Holders

AVT (SHANGHAI) PHARMACEUTICAL TECH CO LTD

United States
Active
Taige Kanglihua (Beijing) Consulting Services Co., Ltd.

China
Active
IPT Consulting Co., Ltd.

China
Active

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