2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[2-[(tetrahydro-2-furanyl)methoxy]phenoxy]-, hydrochloride (1:1)
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![2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[2-[(tetrahydro-2-furanyl)methoxy]phenoxy]-, hydrochloride (1:1) structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220811/efe45029750848478a2bbaa35c8c5a02.png "2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[2-[(tetrahydro-2-furanyl)methoxy]phenoxy]-, hydrochloride (1:1)")
2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[2-[(tetrahydro-2-furanyl)methoxy]phenoxy]-, hydrochloride (1:1)
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CAS No:
35108-88-4
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Formula:
C18H29NO4.ClH
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Chemical Name:
2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[2-[(tetrahydro-2-furanyl)methoxy]phenoxy]-, hydrochloride (1:1)
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Synonyms:
2-Propanol,1-[(1,1-dimethylethyl)amino]-3-[2-[(tetrahydro-2-furanyl)methoxy]phenoxy]-,hydrochloride (1:1);2-Propanol,1-[(1,1-dimethylethyl)amino]-3-[2-[(tetrahydro-2-furanyl)methoxy]phenoxy]-,hydrochloride;DL-1-tert-Butylamino-3-[o-(tetrahydrofurfuryloxy)phenoxy]-2-propanol hydrochloride;Y 6124;1-tert-Butylamino-3-[o-(tetrahydrofurfuryloxy)phenoxy]-2-propanol hydrochloride;Bufetolol-hydrochloride;Adobiol;40851-35-2
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CAS No:
2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[2-[(tetrahydro-2-furanyl)methoxy]phenoxy]-, hydrochloride (1:1) Basic Attributes
359.8881
359.1863361 g/mol
252-369-4
LWE8W5792M
Drug Information
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety. (See all compounds classified as Adrenergic beta-Antagonists.)
1-tert-butylamino-3-(o-(tetrahydrofurfuryloxy)phenoxy)-2-propanol
2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[2-[(tetrahydro-2-furanyl)methoxy]phenoxy]-, hydrochloride (1:1) Use and Manufacturing
To a solution of 1 gramm equivalent (g-eq.) of 1-bromo-3-[2- (tetrahydrofuran-2-yloxy)phenoxy]propan-2-ol in 30 ml of ethanol is added 1 g-eq. of t-butylamine, the mixture is refluxed for 6 hours, and then the ethanol is distilled off. The residue is dissolved in benzene and the solution is extracted twice with 5% oxalic acid. The aqueous extract is made alkaline with potassium hydroxide and the isolated oil is extracted with benzene. The benzene extract is dried over potassium carbonate and the benzene is distilled off to give of oily 1-(t-butylamino)-3-(o-((tetrahydrofurfuryl)oxy)phenoxy)-2- propanol. The corresponding acid fumarate melts at 128°-132°C.
Computed Properties
Molecular Weight:359.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:9
Exact Mass:359.1863361
Monoisotopic Mass:359.1863361
Topological Polar Surface Area:60
Heavy Atom Count:24
Complexity:332
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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