Amocarzine
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Amocarzine
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CAS No:
36590-19-9
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Formula:
C18H21N5O2S
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Chemical Name:
Amocarzine
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Synonyms:
1-Piperazinecarbothioamide,4-methyl-N-[4-[(4-nitrophenyl)amino]phenyl]-;4-Methyl-N-[4-[(4-nitrophenyl)amino]phenyl]-1-piperazinecarbothioamide;S 80016;CGP 6140;Phenthiourezine;Amocarzine;99402-78-5
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CAS No:
Description
Amocarzine is a thiourea resulting from the formal condensation of the secondary amino group of 1-methylpiperazine and the primary amino group of N-(4-nitrophenyl)benzene-1,4-diamine with carbonothioic O,O-acid. It has a role as an antinematodal drug. It is a C-nitro compound, a N-methylpiperazine, a member of thioureas and a secondary amino compound. It derives from a diphenylamine.
Characteristics
108.45000
3.82760
1.361±0.06 g/cm3
191-196 °C
533.6±60.0 °C(Predicted)
276.5ºC
1.715
14.49±0.20
Drug Information
Agents that kill parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal. (See all compounds classified as Anthelmintics.)|Pharmacological agents destructive to nematodes in the superfamily Filarioidea. (See all compounds classified as Filaricides.)
4-nitro-4'-(N-methyl)piperazinyl thiocarbonylidodiphenylamine
Amocarzine Use and Manufacturing
A solution of 4-nitro-4'-isothiocyanodiphenylamine in toluene was treated at 50°C with stirring with a solution N-methylpiperazine in toluene. After 3 hours the solution was filtered from the precipitate obtained. By recrystallization the crude product from methanol the 4-methyl-N-[4-[(4- nitrophenyl)amino]phenyl]-1-piperazinecarbothioamide was obtained; melting point 191-196°C.
Computed Properties
Molecular Weight:371.5
XLogP3:2.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:371.14159610
Monoisotopic Mass:371.14159610
Topological Polar Surface Area:108
Heavy Atom Count:26
Complexity:477
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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