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Molindone hydrochloride

Molindone hydrochloride structure

CAS No:
15622-65-8
Formula:
C16H24N2O2.ClH
Chemical Name:
Molindone hydrochloride
Synonyms:
4H-Indol-4-one,3-ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-,hydrochloride (1:1);Indol-4(5H)-one,3-ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)-,monohydrochloride;4H-Indol-4-one,3-ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-,monohydrochloride;Molindone hydrochloride;EN 1733A;Lindone;Moban;(±)-Molindone hydrochloride;3-Ethyl-2-methyl-5-(morpholinomethyl)-6,7-dihydro-1H-indol-4(5H)-one hydrochloride;3-Ethyl-2-methyl-5-[(morpholin-4-yl)methyl]-4,5,6,7-tetrahydro-1H-indol-4-one hydrochloride
Categories:
Surfactant > Cationic Surfactants

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Molindone hydrochloride Basic Attributes

Molecular Weight：

312.84

Exact Mass：

312.1604557 g/mol

HScode：

2934999090

Characteristics

PSA：

45.33000

XLogP3：

2.70270

Melting Point：

211-213°C

Boiling Point：

462.9ºC

Flash Point：

233.7ºC

Vapor Pressure：

9.51E-09mmHg at 25°C

Toxicity：

LD50 orally in rats: 261 mg/kg (Goldenthal)

Safety Information

Packing level：

III

Hazard category：

6.1

Transport codes：

UN 2811 6.1/PG 3

wgk germany：

hazard class code：

RTECS Number：

NM3325000

Marks：

Precautionary statement(s)：

P301 + P310

Hazard Statements：

H301

Molindone hydrochloride Use and Manufacturing

Methods of Manufacturing

Diethyl ketone may be reacted with methyl nitrite and that product in turn reacted with cyclohexan-1,3-dione to give 3-ethyl-4,5,6,7-tetrahydro-2- methyl-4-oxoindole. 3-ethyl-4,5,6,7-tetrahydro-2-methyl-4-oxoindole 14.1 g (0.08 mol), 14.8 g morpholine hydrochloride (0.12 mol), and 3.6 g paraformaldehyde (0.12 mol) were refluxed in 200 ml ethanol for 40 hours. The solution was evaporated to dryness in vacuo on a steam bath and the residue digested with a mixture of 150 ml water and 10 ml 2N HCl. An insoluble residue of unreacted starting material was filtered off. To the acid solution, ammonia water was added dropwise with stirring and the amine crystallized out. It was purified by dissolving in 1N HCl and addition of ammonia, then by 2 crystallizations from benzene followed by 2 crystallizations from isopropanol, to yield 3-ethyl- 4,5,6,7-tetrahydro-2-methyl-4-oxoindole, melting point 180°C to 181°C.

Uses

Antipsychotic;Dopamine receptor antagonist

Recommended Suppliers of Molindone hydrochloride

Shandong zhishang chemical Co.,Ltd Contact Supplier

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15622-65-8 MOLINDONE HYDROCHLORIDE

CAS No.: 15622-65-8

Grade: Industrial Grade

Content: 98%

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HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

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Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

MOLINDONE HYDROCHLORIDE

CAS No.: 15622-65-8

Content: 99.00%

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