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Pleuromulin

Pleuromulin structure

CAS No:
125-65-5
Formula:
C22H34O5
Chemical Name:
Pleuromulin
Synonyms:
PLEUROMULIN;PLEUROMUTILIN;a4014c;antibioticbc757;bc757;drosopholinb;glycolicacid,8-esterwithoctahydro-5,8-dihydroxy-4,6,9,10-tetramethyl-6-viny;l-3a,9-propano-3ah-cyclopentacycloocten-1(4h)-one
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Pleuromutilin is an antibiotic derived from the fungusClitopilusthat inhibits bacterial protein synthesis by binding to bacterial ribosomes in the peptidyl transferase component of the 50S subunit and inhibiting peptide bond formation.

Pleuromulin is Crystalline Solid

Pleuromulin Basic Attributes

Molecular Weight：

378.5

Exact Mass：

378.50

EC Number：

204-747-5

DSSTox ID：

DTXSID9048720

Color/Form：

white to beige

Characteristics

Density：

1.15±0.1 g/cm3(Predicted)

Melting Point：

170-1710C

Boiling Point：

482.8±45.0 °C(Predicted)

Toxicity：

LD50 in mice: >60 mg/kg (Kavanagh, 1952)

PKA：

12.91±0.10(Predicted)

Critical Temperature & Pressure：

-20°C Freezer

Safety Information

wgk germany：

RTECS Number：

MC5408000

GHS Classification：

|Danger|H302 (80%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P272, P273, P280, P285, P301+P312, P302+P352, P304+P340, P304+P341, P305+P351+P338, P312, P321, P330, P333+P313, P337+P313, P342+P311, P363, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 6 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

MeSH Entry Terms：

Drosophilin B

Pleuromulin Use and Manufacturing

Pleuromutilin is a diterpene produced by several species of basidomycete, notably the genus Pleurotus, discovered in 1951. Pleuromutilin is a potent and highly selective antibiotic active against a range of Gram positive bacteria, with no cross resistance to existing antibiotic classes due to its unique mode of action. Pleuromutilin inhibits protein synthesis by binding to domain V of 23S rRNA and this has led to the development of many semi-synthetic analogues as new generation antibiotics, such as tiamulin and retapamulin.Pleuromutilins such as tiamulin and valnemulin have been used for some time in veterinary medicine to treat swine infections. More recently a semisynthetic pleuromutilin, retapamulin, has been introduced as a topical treatment for Gram-positive infections in humans. Pleuromutilins inhibit the peptidyl transferase activity of the bacterial 50S ribosomal subunit by binding to the A site.

Antibiotic substance produced by the basidiomycetes Pleurotus mutilus.

Recommended Suppliers of Pleuromulin

Cuicheng Biomedical Technology Contact Supplier

CN
1 YR

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Manufactory Supplier of Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5,Ginsenoside Rg5,Ginsenoside Rh2,Protopanaxatriol,Epmedin C,Icariin,Icaritin,Baohuoside I,Total Ginsenosides,Total Ginsenosides from Ginseng Stems And Leaves,Oridonin,Oleuropein,Curcumin,(20)-Ginsenoside Rg3,(20)-Protopanaxadiol

Pleuromutilin

Unit Price: $370-400 /KG FOB

CAS No.: 125-65-5

Grade: Industrial Grade

Content: 98%

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HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Pleuromulin

CAS No.: 125-65-5

Content: 99.00%

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