Lerisetron
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Lerisetron
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CAS No:
143257-98-1
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Formula:
C18H20N4
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Chemical Name:
Lerisetron
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Synonyms:
1H-Benzimidazole,1-(phenylmethyl)-2-(1-piperazinyl)-;1-(Phenylmethyl)-2-(1-piperazinyl)-1H-benzimidazole;1-Benzyl-2-(1-piperazinyl)benzimidazole;Lerisetron;1-Benzyl-2-(piperazin-1-yl)-1H-1,3-benzodiazole
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CAS No:
Description
Lerisetron has been used in trials studying the supportive care of Nausea and Vomiting and Testicular Germ Cell Tumor.|Lerisetron is the hydrochloride salt of a 2-piperazinylbenzimidazole-derivative serotonin type 3 (5-HT3) receptor antagonist with antiemetic activity. Lerisetron specifically binds to 5-HT3 receptors, located peripherally on vagus nerve terminals and centrally in the chemoreceptor trigger zone (CTZ) of the area postrema, which may result in suppression of chemotherapy-induced nausea and vomiting.
Safety Information
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Computed Properties
Molecular Weight:292.4
XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:292.16879665
Monoisotopic Mass:292.16879665
Topological Polar Surface Area:33.1
Heavy Atom Count:22
Complexity:349
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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