4-[2-[4-[(E)-3-ethoxyprop-1-enyl]phenyl]-4-[4-(propan-2-ylamino)phenyl]-1H-imidazol-5-yl]-N-propan-2-ylaniline
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![4-[2-[4-[(E)-3-ethoxyprop-1-enyl]phenyl]-4-[4-(propan-2-ylamino)phenyl]-1H-imidazol-5-yl]-N-propan-2-ylaniline structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/4eef31f3309a451e91348e3278800bad.png "4-[2-[4-[(E)-3-ethoxyprop-1-enyl]phenyl]-4-[4-(propan-2-ylamino)phenyl]-1H-imidazol-5-yl]-N-propan-2-ylaniline")
4-[2-[4-[(E)-3-ethoxyprop-1-enyl]phenyl]-4-[4-(propan-2-ylamino)phenyl]-1H-imidazol-5-yl]-N-propan-2-ylaniline
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CAS No:
216227-54-2
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Formula:
C32H38N4O
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Chemical Name:
4-[2-[4-[(E)-3-ethoxyprop-1-enyl]phenyl]-4-[4-(propan-2-ylamino)phenyl]-1H-imidazol-5-yl]-N-propan-2-ylaniline
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Synonyms:
OC 144-093; ONT 093; Benzenamine,4,4'-(2-(4-((1E)-3-ethoxy-1-propenyl]phenyl)-1H-imidazole-4,5-diyl)bis(N-(1-methylethyl);
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CAS No:
Description
ONT-093 is an orally bioavailable inhibitor of P-glycoprotein (P-gp). In pre-clinical studies, ONT-093 could inhibit P-gp and reverse multidrug resistance at nM concentrations with no effect on paclitaxel pharmacokinetics.
4-[2-[4-[(E)-3-ethoxyprop-1-enyl]phenyl]-4-[4-(propan-2-ylamino)phenyl]-1H-imidazol-5-yl]-N-propan-2-ylaniline Basic Attributes
494.67000
494.30456185
PK2WD2XC83
Computed Properties
Molecular Weight:494.7
XLogP3:7.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:11
Exact Mass:494.30456185
Monoisotopic Mass:494.30456185
Topological Polar Surface Area:62
Heavy Atom Count:37
Complexity:658
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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