N1,N11-Diethylnorspermine
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N1,N11-Diethylnorspermine
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CAS No:
121749-39-1
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Formula:
C13H32N4
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Chemical Name:
N1,N11-Diethylnorspermine
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Synonyms:
1,3-Propanediamine,N1,N3-bis[3-(ethylamino)propyl]-;1,3-Propanediamine,N,N′-bis[3-(ethylamino)propyl]-;N1,N3-Bis[3-(ethylamino)propyl]-1,3-propanediamine;N1,N11-Diethylnorspermine;N1,N11-Bis(ethyl)norspermine;DENSPM;BE 3-3-3;DE 333;BENSPM;Diethyl-norspermine;BE 333;1,3-Propanediamine N1,N3-bis[3-(ethylamino)propyl]-
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CAS No:
Description
Diethylnorspermine is a synthetic bis-ethyl analogue of spermine with potential antineoplastic activity. N(1),N(11)-bis(ethyl)norspermine (DENSPM), a N-terminally alkylated tetraamine and polyamine mimetics, disrupts polyamine pool homeostasis by modulating the activities of the biosynthetic enzymes, ornithine decarboxylase (ODC), and S-adenosylmethionine decarboxylase (AdoMetDC). This agent also reduces polyamine concentrations through the induction of the catabolic enzyme spermidine/spermine N1-acetyltransferase 1 (SSAT). Polyamines, an integral part of the DNA helix structure, play a critical role in cell division, differentiation and membrane function. Disruption of normal polyamine concentrations by DENSPM may lead to cell growth inhibition.
Drug Information
Investigated for use/treatment in renal cell carcinoma, pancreatic cancer, melanoma, and lung cancer.
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)
1,11-bis(ethylamino)-4,8-diazaundecane
Computed Properties
Molecular Weight:244.42
XLogP3:0.3
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:14
Exact Mass:244.26269704
Monoisotopic Mass:244.26269704
Topological Polar Surface Area:48.1
Heavy Atom Count:17
Complexity:117
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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