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(2S)-N-[3-(1,3-Benzodioxol-5-yloxy)propyl]-2,3-dihydro-1,4-benzodioxin-2-methanamine hydrochloride (1:1)

(2S)-N-[3-(1,3-Benzodioxol-5-yloxy)propyl]-2,3-dihydro-1,4-benzodioxin-2-methanamine hydrochloride (1:1) structure

CAS No:
137275-80-0
Formula:
C19H21NO5.ClH
Chemical Name:
(2S)-N-[3-(1,3-Benzodioxol-5-yloxy)propyl]-2,3-dihydro-1,4-benzodioxin-2-methanamine hydrochloride (1:1)
Synonyms:
1,4-Benzodioxin-2-methanamine,N-[3-(1,3-benzodioxol-5-yloxy)propyl]-2,3-dihydro-,hydrochloride (1:1),(2S)-;1,4-Benzodioxin-2-methanamine,N-[3-(1,3-benzodioxol-5-yloxy)propyl]-2,3-dihydro-,hydrochloride,(S)-;1,4-Benzodioxin-2-methanamine,N-[3-(1,3-benzodioxol-5-yloxy)propyl]-2,3-dihydro-,hydrochloride,(2S)-;(2S)-N-[3-(1,3-Benzodioxol-5-yloxy)propyl]-2,3-dihydro-1,4-benzodioxin-2-methanamine hydrochloride (1:1);MKC 242

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Description

MN-305 is a novel, potent and highly selective serotonin 5-HT1A receptor agonist under development by MediciNova for the treatment of anxiety disorders beginning with Generalized Anxiety Disorder (GAD).

(2S)-N-[3-(1,3-Benzodioxol-5-yloxy)propyl]-2,3-dihydro-1,4-benzodioxin-2-methanamine hydrochloride (1:1) Basic Attributes

Molecular Weight：

379.83500

Exact Mass：

379.1186505 g/mol

UNII：

F0WKFYPQL8

Characteristics

PSA：

58.18000

XLogP3：

3.80670

Boiling Point：

491.5ºC

Flash Point：

203.8ºC

Vapor Pressure：

8.32E-10mmHg at 25°C

Drug Information

Drug Indication：

Investigated for use/treatment in anxiety disorders, depression, insomnia, and neurologic disorders.

Mechanism of Action：

MN-305 is a potent and highly-selective full agonist at the serotonin 5-HT1A receptor under development by MediciNova both for the treatment of insomnia, as well as for anxiety disorders such as Generalized Anxiety Disorder (GAD). MN-305 has been evaluated in an extensive preclinical toxicology program which showed no evidence of inducing genetic mutations, immune response or cancer. MN-305 has also proved to be consistently well-tolerated in clinical safety, efficacy and pharmacokinetic studies in over 1,200 subjects.

MeSH Entry Terms：

5-(3-((1,4-benzodioxan-2-ylmethyl)amino)propoxy)-1,3-benzodioxole hydrochloride

Computed Properties

Molecular Weight:379.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:379.1186505
Monoisotopic Mass:379.1186505
Topological Polar Surface Area:58.2
Heavy Atom Count:26
Complexity:409
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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Guide of (2S)-N-[3-(1,3-Benzodioxol-5-yloxy)propyl]-2,3-dihydro-1,4-benzodioxin-2-methanamine hydrochloride (1:1)

Description
Basic Attributes
Characteristics
Drug Information
Computed Properties
Learn More Other Chemicals

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