Dioxifedrine
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Dioxifedrine
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CAS No:
10329-60-9
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Formula:
C10H15NO3
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Chemical Name:
Dioxifedrine
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Synonyms:
1,2-Benzenediol,4-[1-hydroxy-2-(methylamino)propyl]-;Benzyl alcohol,3,4-dihydroxy-α-[1-(methylamino)ethyl]-;4-[1-Hydroxy-2-(methylamino)propyl]-1,2-benzenediol;3,4-Dihydroxy-α-[1-(methylamino)ethyl]benzyl alcohol;1-(3,4-Dihydroxyphenyl)-2-methylaminopropanol;α-Methyladrenaline;Dioxyephedrine;Sor-N 49;Diphedran;LD 1205;Dioxifedrine;713-49-5;28148-77-8
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CAS No:
Description
Dioxifedrine is a beta-2 -adrenergic agonist with bronchodilator activity. Dioxifedrine selectively binds to and activates beta-2 adrenergic receptors in bronchiolar smooth muscle, thereby causing stimulation of adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased intracellular cAMP levels cause relaxation of bronchial smooth muscle. This increases air flow and prevents bronchospasms and may eventually lead to an improvement of airway function.
Characteristics
72.72000
1.13000
1.236g/cm3
165-170 °C @ Press: 2 Torr
190ºC
1.59
1.89E-07mmHg at 25°C
Computed Properties
Molecular Weight:197.23
XLogP3:-0.3
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:197.10519334
Monoisotopic Mass:197.10519334
Topological Polar Surface Area:72.7
Heavy Atom Count:14
Complexity:177
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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