Piritrexim
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Piritrexim
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CAS No:
72732-56-0
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Formula:
C17H19N5O2
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Chemical Name:
Piritrexim
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Synonyms:
Pyrido[2,3-d]pyrimidine-2,4-diamine,6-[(2,5-dimethoxyphenyl)methyl]-5-methyl-;6-[(2,5-Dimethoxyphenyl)methyl]-5-methylpyrido[2,3-d]pyrimidine-2,4-diamine;BW 301U;NSC 351521;Piritrexim
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CAS No:
Description
Piritrexim has been used in trials studying the treatment of Bladder Cancer, Urethral Cancer, and Transitional Cell Cancer of the Renal Pelvis and Ureter.|Piritrexim is a synthetic antifolate agent with antiparasitic, antipsoriatic and antitumor properties. Piritrexim inhibits the enzyme dihydrofolate reductase enzyme, thereby disrupting folate metabolism and DNA synthesis and cell division. (NCI04)
Drug Information
Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033) (See all compounds classified as Folic Acid Antagonists.)|Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)
2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido(2,3-d)pyrimidine
Computed Properties
Molecular Weight:325.4
XLogP3:2.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:325.15387487
Monoisotopic Mass:325.15387487
Topological Polar Surface Area:109
Heavy Atom Count:24
Complexity:412
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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