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Ethyl 4-[2-(difluoromethoxy)phenyl]-1,4,5,7-tetrahydro-2-methyl-5-oxofuro[3,4-b]pyridine-3-carboxylate

Ethyl 4-[2-(difluoromethoxy)phenyl]-1,4,5,7-tetrahydro-2-methyl-5-oxofuro[3,4-b]pyridine-3-carboxylate structure

CAS No:
89289-93-0
Formula:
C18H17F2NO5
Chemical Name:
Ethyl 4-[2-(difluoromethoxy)phenyl]-1,4,5,7-tetrahydro-2-methyl-5-oxofuro[3,4-b]pyridine-3-carboxylate
Synonyms:
Furo[3,4-b]pyridine-3-carboxylic acid,4-[2-(difluoromethoxy)phenyl]-1,4,5,7-tetrahydro-2-methyl-5-oxo-,ethyl ester;Ethyl 4-[2-(difluoromethoxy)phenyl]-1,4,5,7-tetrahydro-2-methyl-5-oxofuro[3,4-b]pyridine-3-carboxylate;CGP 28392;CIBA 28392;IOS 2456;(±)-CGP 28392;RS 71684;123386-97-0

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Description

CGP 28-392 is an aromatic ether.

Ethyl 4-[2-(difluoromethoxy)phenyl]-1,4,5,7-tetrahydro-2-methyl-5-oxofuro[3,4-b]pyridine-3-carboxylate Basic Attributes

Molecular Weight：

365.3 g/mol

Exact Mass：

365.33

Characteristics

PSA：

73.9 Å²

Melting Point：

173-175 °C @ Solvent: Methanol, Water

Drug Information

MeSH：

Agents that increase calcium influx into calcium channels of excitable tissues. This causes vasoconstriction in VASCULAR SMOOTH MUSCLE and/or CARDIAC MUSCLE cells as well as stimulation of insulin release from pancreatic islets. Therefore, tissue-selective calcium agonists have the potential to combat cardiac failure and endocrinological disorders. They have been used primarily in experimental studies in cell and tissue culture. (See all compounds classified as Calcium Channel Agonists.)

MeSH Entry Terms：

2-methyl-3-methoxycarbonyl-4-(2'-difluoromethoxyphenyl)-5-oxo-1,4,5,7-tetrahydrofuro(3,4-b)pyridine

Computed Properties

Molecular Weight:365.3
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:6
Exact Mass:365.10747897
Monoisotopic Mass:365.10747897
Topological Polar Surface Area:73.9
Heavy Atom Count:26
Complexity:658
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of Ethyl 4-[2-(difluoromethoxy)phenyl]-1,4,5,7-tetrahydro-2-methyl-5-oxofuro[3,4-b]pyridine-3-carboxylate

Description
Basic Attributes
Characteristics
Drug Information
Computed Properties
Learn More Other Chemicals

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