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Atiprimod

Atiprimod structure

CAS No:
123018-47-3
Formula:
C22H44N2
Chemical Name:
Atiprimod
Synonyms:
2-Azaspiro[4.5]decane-2-propanamine,N,N-diethyl-8,8-dipropyl-;N,N-Diethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanamine;Atiprimod;Azaspirane

Description

Atiprimod is an orally bioavailable small molecule belonging to the azaspirane class of cationic amphiphilic agents with anti-inflammatory, antineoplastic, and antiangiogenic properties. Atiprimod inhibits the phosphorylation of signal transducer and activator of transcription 3 (STAT3), blocking the signalling pathways of interleukin-6 and vascular endothelial growth factor (VEGF) and downregulating the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1, thereby inhibiting cell proliferation, inducing cell cycle arrest, and inducing apoptosis.

Atiprimod Basic Attributes

Molecular Weight：

336.6 g/mol

Exact Mass：

336.60

UNII：

MG7D3QD743

DSSTox ID：

DTXSID10153834

NCI Thesaurus Code：

C52184

Characteristics

PSA：

6.5 Å²

Drug Information

Drug Indication：

Investigated for use/treatment in cancer/tumors (unspecified), multiple myeloma, and rheumatoid arthritis.

MeSH Entry Terms：

antiprimod

Computed Properties

Molecular Weight:336.6
XLogP3:6.6
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:10
Exact Mass:336.350449412
Monoisotopic Mass:336.350449412
Topological Polar Surface Area:6.5
Heavy Atom Count:24
Complexity:332
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of Atiprimod

Description
Basic Attributes
Characteristics
Drug Information
Computed Properties

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