Lefradafiban
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Lefradafiban
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CAS No:
149503-79-7
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Formula:
C23H25N3O6
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Chemical Name:
Lefradafiban
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Synonyms:
3-Pyrrolidineacetic acid,5-[[[4′-[imino[(methoxycarbonyl)amino]methyl][1,1′-biphenyl]-4-yl]oxy]methyl]-2-oxo-,methyl ester,(3S,5S)-;3-Pyrrolidineacetic acid,5-[[[4′-[imino[(methoxycarbonyl)amino]methyl][1,1′-biphenyl]-4-yl]oxy]methyl]-2-oxo-,methyl ester,(3S-trans)-;Lefradafiban;BIBU 104XX
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CAS No:
Description
Lefradafiban is a member of the class of pyrrolidin-2-ones that is pyrrolidin-2-one in which the 3-pro-S-hydrogen is substituted by a 2-methoxy-2-oxoethyl group, while the 5-pro-S-hydrogen is substituted by a ({4'-[N-(methoxycarbonyl)carbamimidoyl]biphenyl-4-yl}oxy)methyl group. It is an orally active prodrug of fradafiban, a figrinogen receptor antagonist. It has a role as a prodrug and a platelet glycoprotein-IIb/IIIa receptor antagonist. It is a member of pyrrolidin-2-ones and a methyl ester. It derives from a fradafiban.|Lefradafiban is an oral platelet glycoprotein IIb/IIIa receptor antagonist being investigated in the treatment of angina.
Drug Information
For the treatment of unstable angina.
Lefradafiban, an orally active prodrug of fradafiban, is a novel glycoprotein (IIb/IIIa) inhibitor for the treatment of unstable angina. Development was discontinued in 2000 due to lack of efficacy.
GPIIb/IIIa inhibitors, such as lefradafiban, block the final common pathway of platelet aggregation.
Computed Properties
Molecular Weight:439.5
XLogP3:2.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:9
Exact Mass:439.17433553
Monoisotopic Mass:439.17433553
Topological Polar Surface Area:129
Heavy Atom Count:32
Complexity:696
Defined Atom Stereocenter Count:2
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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