3-(2-aminoethoxymethyl)-2,5,9-trimethylfuro[3,2-g]chromen-7-one
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![3-(2-aminoethoxymethyl)-2,5,9-trimethylfuro[3,2-g]chromen-7-one structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/8f631750ddfa451685e3fa7beeadf4bc.png "3-(2-aminoethoxymethyl)-2,5,9-trimethylfuro[3,2-g]chromen-7-one")
3-(2-aminoethoxymethyl)-2,5,9-trimethylfuro[3,2-g]chromen-7-one
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CAS No:
161262-29-9
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Formula:
C17H19NO4
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Chemical Name:
3-(2-aminoethoxymethyl)-2,5,9-trimethylfuro[3,2-g]chromen-7-one
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Synonyms:
amotosalen;amotosalen hydrochloride;Amotosalen;UNII-K1LDZ0VBC0;Amotosalen free base;K1LDZ0VBC0;161262-29-9;161262-29-9 (free base);7H-Furo(3,2-g)(1)benzopyran-7-one, 3-((2-aminoethoxy)methyl)-2,5,9-trimethyl-;Amotosalen [INN];SCHEMBL599618;CHEMBL2110621;3-(2-aminoethoxymethyl)-2,5,9-trimethylfuro[3,2-g]chromen-7-one;Q9150146;3-((2-Aminoethoxy)methyl)-2,5,9-trimethyl-7H-furo(3,2-g)(1)benzopyran-7-one
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CAS No:
Description
Amotosalen is a synthetic psoralen, light-activated DNA and RNA crosslinking agent, with protective activity against pathogens such as bacteria, viruses, protozoa, and leukocytes. Prior to administration amotosalen is added to plasma and platelets, then in vivo this agent penetrates pathogens and targets DNA and RNA. Upon activation by ultraviolet A light, this agent is able to form interstrand DNA and RNA crosslinks and prevents replication. Inactivation of leukocytes can prevent graft versus host disease upon transfusion.
3-(2-aminoethoxymethyl)-2,5,9-trimethylfuro[3,2-g]chromen-7-one Basic Attributes
301.34 g/mol
301.13140809 g/mol
K1LDZ0VBC0
C76756
Drug Information
Drugs that are pharmacologically inactive but when exposed to ultraviolet radiation or sunlight are converted to their active metabolite to produce a beneficial reaction affecting the diseased tissue. These compounds can be administered topically or systemically and have been used therapeutically to treat psoriasis and various types of neoplasms. (See all compounds classified as Photosensitizing Agents.)|Drugs used to treat or prevent skin disorders or for the routine care of skin. (See all compounds classified as Dermatologic Agents.)
amotosalen
Computed Properties
Molecular Weight:301.34
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:301.13140809
Monoisotopic Mass:301.13140809
Topological Polar Surface Area:74.7
Heavy Atom Count:22
Complexity:464
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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