Indisulam
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Indisulam
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CAS No:
165668-41-7
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Formula:
C14H12ClN3O4S2
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Chemical Name:
Indisulam
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Synonyms:
1,4-Benzenedisulfonamide,N1-(3-chloro-1H-indol-7-yl)-;1,4-Benzenedisulfonamide,N-(3-chloro-1H-indol-7-yl)-;N1-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide;E 7070;Indisulam
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CAS No:
Description
Indisulam is a chloroindole that is 3-chloro-1H-indole substituted by a [(4-sulfamoylphenyl)sulfonyl]nitrilo group at position 7. It is a carbonic anhydrase inhibitor and a potential anti-cancer agent currently in clinical development. It has a role as an EC 4.2.1.1 (carbonic anhydrase) inhibitor and an antineoplastic agent. It is a chloroindole, a sulfonamide and an organochlorine compound.|Indisulam is a novel sulfonamide compound with potential antineoplastic activity. Indisulam inhibits cyclin-dependent kinases (CDK), which regulate cell cycle progression and are usually over-expressed in cancerous cells. Inhibition of CDK results in G1/S phase arrest of the cell cycle, and may lead to induction of apoptosis and inhibition of tumor cell proliferation. In addition, indisulam also inhibits carbonic anhydrases (CA), especially isoforms IX and XII that are involved in aqueous humor production and are highly overexpressed in some types of cancers. Inhibition of CA IX and XII results in interference with ion exchange and pH in hypoxic tumor tissue and preventing chemoresistance to weakly basic antineoplastic agents.
Drug Information
Investigated for use/treatment in lung cancer.
Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)|A class of compounds that reduces the secretion of H+ ions by the proximal kidney tubule through inhibition of CARBONIC ANHYDRASES. (See all compounds classified as Carbonic Anhydrase Inhibitors.)
E7070 is a novel sulfonamide antitumoragent that exhibits potent antitumoractivity in vitro and in vivo. This compound affects cell cycleprogression in human tumor cells
E 7070
Computed Properties
Molecular Weight:385.8
XLogP3:1.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:384.9957759
Monoisotopic Mass:384.9957759
Topological Polar Surface Area:139
Heavy Atom Count:24
Complexity:651
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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