9-methyl-N-[2-[2-[2-[(9-methylphenazine-1-carbonyl)amino]ethylamino]ethylamino]ethyl]phenazine-1-carboxamide
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![9-methyl-N-[2-[2-[2-[(9-methylphenazine-1-carbonyl)amino]ethylamino]ethylamino]ethyl]phenazine-1-carboxamide structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/654f7b00c4344c1f9e3bdb1ffbcb855a.png "9-methyl-N-[2-[2-[2-[(9-methylphenazine-1-carbonyl)amino]ethylamino]ethylamino]ethyl]phenazine-1-carboxamide")
9-methyl-N-[2-[2-[2-[(9-methylphenazine-1-carbonyl)amino]ethylamino]ethylamino]ethyl]phenazine-1-carboxamide
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CAS No:
343247-32-5
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Formula:
C34H34N8O2
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Chemical Name:
9-methyl-N-[2-[2-[2-[(9-methylphenazine-1-carbonyl)amino]ethylamino]ethylamino]ethyl]phenazine-1-carboxamide
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Synonyms:
XR 5944;XR5944;XR 5944;343247-32-5;xr5944;N,N'-(1,2-Ethanediylbis(imino-2,1-ethanediyl))bis(9-methyl-1-phenazinecarboxamide);XR-5944;1-Phenazinecarboxamide, N,N'-(1,2-ethanediylbis(imino-2,1-ethanediyl))bis(9-methyl-;1-Phenazinecarboxamide, N,N'-[1,2-ethanediylbis(imino-2,1-ethanediyl)]bis[9-methyl-;MLN 944;CHEMBL30424;SCHEMBL626969;DTXSID10187891;NSC754366;DB06364;NSC-754366;9-methyl-N-[2-[2-[2-[(9-methylphenazine-1-carbonyl)amino]ethylamino]ethylamino]ethyl]phenazine-1-carboxamide;N,N'-[Ethylenebis(iminoethylene)]bis(9-methylphenazine-1-carboxamide);N,NO Bis[2-(9-methylphenazine-1-carboxamido)ethyl]-1,2-ethanediamine
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CAS No:
Description
XR5944 is a DNA bis-intercalating anticancer drug. It has both intercalating and antineoplastic activities.
9-methyl-N-[2-[2-[2-[(9-methylphenazine-1-carbonyl)amino]ethylamino]ethylamino]ethyl]phenazine-1-carboxamide Basic Attributes
586.7 g/mol
586.28047236 g/mol
DTXSID10187891
Drug Information
Investigated for use/treatment in solid tumors.
XR5944 is a novel DNA targeting agent that in preclinical studies has demonstrated a high level of anti-tumor activity, both in vitro and in vivo, against a number of human tumor models. In human tumor xenograft models, treatment with XR5944 caused both partial and complete regression of large established tumors.
XR 5944
Computed Properties
Molecular Weight:586.7
XLogP3:3.5
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:11
Exact Mass:586.28047236
Monoisotopic Mass:586.28047236
Topological Polar Surface Area:134
Heavy Atom Count:44
Complexity:878
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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