Pyridine, 2-methyl-6-(2-phenylethynyl)-, hydrochloride (1:1)

2-methyl-6-(phenylethynyl)pyridine hydrochloride is a hydrochloride salt obtained by reaction of 2-methyl-6-(phenylethynyl)pyridine with one equivalent of hydrochloric acid. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw. It has a role as a metabotropic glutamate receptor antagonist and an anxiolytic drug. It contains a 2-methyl-6-(phenylethynyl)pyridinium(1+).

Molecular Weight:229.70
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:229.0658271
Monoisotopic Mass:229.0658271
Topological Polar Surface Area:12.9
Heavy Atom Count:16
Complexity:251
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes