PHT-GLY-OTBU
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PHT-GLY-OTBU
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CAS No:
6297-93-4
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Formula:
C14H15NO4
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Chemical Name:
PHT-GLY-OTBU
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Synonyms:
NSC126801;PHT-GLY-OTBU;Phthaloyl-glycinetertutylester;PHTHALYL-GLYCINE T-BUTYL ESTER;PHTHALOYL-GLYCINE T-BUTYL ESTER;Phthaloyl-glycine tert·butyl ester
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CAS No:
Characteristics
63.7
2.2
1.245±0.06 g/cm3(Predicted)
96.0-97.5 °C(Solv: benzene (71-43-2); ligroine (8032-32-4))
370.8°C at 760 mmHg
Safety Information
P264, P270, P273, P301+P310, P321, P330, P391, P405, P501
H301
|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P273, P301+P310, P321, P330, P391, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
PHT-GLY-OTBU Use and Manufacturing
tert-Butyl bromoacetate (10 g, 51 mmol) was charged to a 250 mL 3-neck flask fitted with a thermocouple, nitrogen inlet tube and magnetic stirrer. The flask was charged with acetone (100 mL) and tetrabutylammonium bromide (0.8 g, 2.5 mmol) was added. Potassium phthalimide was next added in one portion and the flask was heated to 45 °C for 15 h. After this time the reaction mixture was cooled to 21 C and the acetone was removed by concentration on a rotovap. EtOAc (100 mL) and water (30 mL) were added. The biphasic mixture was allowed to stir at 21 C for 20 min then the layers were separated. The organic layer was washed with saturated Na