Cyclobenzaprine hydrochloride
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Cyclobenzaprine hydrochloride
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CAS No:
6202-23-9
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Formula:
C20H21N.ClH
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Chemical Name:
Cyclobenzaprine hydrochloride
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Synonyms:
1-Propanamine,3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-,hydrochloride (1:1);5H-Dibenzo[a,d]cycloheptene-Δ5,γ-propylamine,N,N-dimethyl-,hydrochloride;1-Propanamine,3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-,hydrochloride;Proheptatriene hydrochloride;MK 130 hydrochloride;10,11δ-Amitriptyline hydrochloride;Cyclobenzaprine hydrochloride;Lisseril;Flexeril;Tensodox;Yurelax;Benzamin;Flexiban;Miosan;Multi-Relax;Tonmya;TNX-102 SL
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CAS No:
Description
Cyclobenzaprine Hcl is a skeletal muscle relaxant and a central nervous system (CNS) depressant.Target: 5-HT Receptor 2ACyclobenzaprine is a skeletal muscle relaxant and a central nervous system (CNS) depressant. Cyclobenzaprine was thought to be an alpha 2-adrenoceptor agonist that reduced muscle tone by decreasing the activity of descending noradrenergic neurons. Cyclobenzaprine reduced the monosynaptic reflex amplitude dose dependently and this effect was not inhibited by the alpha 2-
Cyclobenzaprine hydrochloride is the hydrochloride salt of cyclobenzaprine. A centrally acting skeletal muscle relaxant, it is used in the symptomatic treatment of painful muscle spasm. It has a role as a muscle relaxant and an antidepressant. It contains a cyclobenzaprine. It derives from a hydride of a dibenzo[a,d][7]annulene.|Cyclobenzaprine Hydrochloride is a centrally acting muscle relaxant, chemically similar to amitriptyline hydrochloride with antidepressant activity. The exact mechanism of action of cyclobenzaprine hydrochloride has not been fully determined. However, it primarily acts at the brain stem to reduce tonic somatic motor activity, influencing both gamma and alpha motor neurons. This leads to a reduction in muscle spasms.
Cyclobenzaprine hydrochloride Basic Attributes
311.85
311.144073
228-264-4
0VE05JYS2P
758414|173379|169900|78206
DTXSID2045105
C47465
2921499090
Characteristics
3.2
5.35580
Crystalline Solid
216-218 °C
405.9ºC at 760 mmHg
9℃
-20°C Freezer
LD50 in mice (mg/kg): 35 i.v., 250 orally (Metysova)
Safety Information
Ⅲ
6.1(b)
UN 2811 6.1/PG 3
3
20/21/22-39/23/24/25-23/24/25-11
36-45-36/37-16-7
HP0875000
Xn,T,F
P210-P260-P280-P301 + P310-P311
H225-H301 + H311 + H331-H370
|Danger|H301 (90.74%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P272, P280, P301+P310, P302+P352, P304+P312, P304+P340, P312, P321, P322, P330, P333+P313, P363, P405, and P501|Aggregated GHS information provided by 55 companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system. (See all compounds classified as Antidepressive Agents, Tricyclic.)|A traditional grouping of drugs said to have a soothing or calming effect on mood, thought, or behavior. Included here are the ANTI-ANXIETY AGENTS (minor tranquilizers), ANTIMANIC AGENTS, and the ANTIPSYCHOTIC AGENTS (major tranquilizers). These drugs act by different mechanisms and are used for different therapeutic purposes. (See all compounds classified as Tranquilizing Agents.)|A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358) (See all compounds classified as Muscle Relaxants, Central.)
cyclobenzaprine
Cyclobenzaprine hydrochloride Use and Manufacturing
Use as muscle relaxant (skeletal)
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:311.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:3
Exact Mass:311.1440774
Monoisotopic Mass:311.1440774
Topological Polar Surface Area:3.2
Heavy Atom Count:22
Complexity:365
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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