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Cyclopenthiazide

Cyclopenthiazide structure

CAS No:
742-20-1
Formula:
C13H18ClN3O4S2
Chemical Name:
Cyclopenthiazide
Synonyms:
2H-1,2,4-Benzothiadiazine-7-sulfonamide,6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-,1,1-dioxide;Su 8341;6-Chloro-3-(cyclopentylmethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide;6-Chloro-3-(cyclopentylmethyl)-3,4-dihydro-7-sulfamyl-2H-1,2,4-benzothiadiazine 1,1-dioxide;Cyclopenthiazide;Navidrex;Salimed;Cyclomethiazide;6-Chloro-3-cyclopentylmethyl-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide;Cyclometiazid;Cyclopentiazid;Navidreks;Benesal;Ciba 8341-Su;Salurilo-C;Ultra-Minzil;Navidrix;Salimid;Tsiklometiazid;NSC 107679;96782-85-3
Categories:
Active Pharmaceutical Ingredients > Urinary System Drugs

Description

6-chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide is a benzothiadiazine.|Cyclopenthiazide is a thiazide diuretic with antihypertensive properties. In a double blind, randomized crossover study, cyclopenthiazide was effective in reducing diastolic blood pressure in mildly hypertensive non-insulin dependent diabetic patients. It is a positive allosteric modulator at AMPA-A receptors.|Thiazide diuretic also used as an antihypertensive agent.

Cyclopenthiazide Basic Attributes

Molecular Weight：

379.88

Exact Mass：

379.88

EC Number：

212-012-5

UNII：

T7817XC41U|866GEV195O

NSC Number：

107679

DSSTox ID：

DTXSID4022868

ATC Code：

C - Cardiovascular system

Characteristics

PSA：

135

XLogP3：

1.58

Appearance：

crystals

Density：

1.5±0.1 g/cm3

Melting Point：

238 °C

Boiling Point：

605.6±65.0 °C at 760 mmHg

Flash Point：

320.1±34.3 °C

Refractive Index：

1.601

Water Solubility：

50mg/L(room temperature)

Toxicity：

LD50 in rats, mice (mg/kg): 141.8 ±24, 232.4 ±25 i.v. (Barrett)

Drug Information

MeSH：

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|Agents that promote the excretion of urine through their effects on kidney function. (See all compounds classified as Diuretics.)|Agents that inhibit SODIUM CHLORIDE SYMPORTERS. They act as DIURETICS. Excess use is associated with HYPOKALEMIA. (See all compounds classified as Sodium Chloride Symporter Inhibitors.)

MeSH Entry Terms：

Cyclomethiazide

Cyclopenthiazide Use and Manufacturing

Antihypertensive;Sodium Chloride Symporter Inhibitor

Computed Properties

Molecular Weight:379.9
XLogP3:1.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:379.0427261
Monoisotopic Mass:379.0427261
Topological Polar Surface Area:135
Heavy Atom Count:23
Complexity:637
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

A medium-acting diuretic that reduces water and sodium retention, thereby lowering blood volume and circulating blood volume, thus having a blood pressure-lowering effect.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Compound Tetrazine Reserpine Tablets
Ingredients	This product is a compound preparation, and its components are: each tablet contains 0.03 mg of reserpine, 1 mg of hydralazine hydrochloride, 1.5 mg of hydrochlorothiazide, 0.025 mg of cyclopenthiazide, 2 mg of promethazine hydrochloride, 1 mg of vitamin B1, 1 mg of vitamin B6, 5 mg of rutin, 30 mg of potassium chloride, and 2.5 mg of chloroquine phosphate.
Indication	1. Reserpine (1) When used in combination with ethanol or CNS depressants, it can increase the central nervous system inhibitory effect. (2) When used in combination with other antihypertensive drugs or diuretics, it can enhance the antihypertensive effect and requires dose adjustment. When used in combination with beta-blockers, the latter's effect can be enhanced. (3) When used in combination with digitalis or quinidine, large doses can cause arrhythmias. (4) When used in combination with levodopa, dopamine depletion can occur, leading to Parkinson's disease. (5) When used in combination with indirect adrenergic drugs such as ephedrine and amphetamine, catecholamine storage can be depleted, inhibiting the effect of adrenergic drugs. (6) When used in combination with direct adrenergic drugs such as epinephrine, isoproterenol, norepinephrine, metaraminol, phenylephrine, etc., their effects can be prolonged. (7) When used in combination with tricyclic antidepressants, reserpine and antidepressants can interact with each other.
Specifications	Compound
Manufacturer	Kaifeng Kangnuo Pharmaceutical Co., Ltd.

Cyclopenthiazine
Specifications	－－－－
Manufacturer	Zhengzhou Taifeng Pharmaceutical Co., Ltd.

Compound Tetrazine Reserpine Tablets
Ingredients	Cyclopenthiazine, promethazine hydrochloride, vitamin B1, chloroquine phosphate, potassium oxide, etc.
Indication	1. Reserpine (1) When used in combination with ethanol or CNS depressants, it can increase the central nervous system inhibitory effect. (2) When used in combination with other antihypertensive drugs or diuretics, it can enhance the antihypertensive effect and requires dose adjustment. When used in combination with beta-blockers, the latter's effect can be enhanced. (3) When used in combination with digitalis or quinidine, large doses can cause arrhythmias. (4) When used in combination with levodopa, dopamine depletion can occur, leading to Parkinson's disease. (5) When used in combination with indirect adrenergic drugs such as ephedrine and amphetamine, catecholamine storage can be depleted, inhibiting the effect of adrenergic drugs. (6) When used in combination with direct adrenergic drugs such as epinephrine, isoproterenol, norepinephrine, metaraminol, phenylephrine, etc., their effects can be prolonged. (7) When used in combination with tricyclic antidepressants, reserpine and antidepressants can interact with each other.
Specifications	Each tablet contains 0.03 mg of reserpine, 1 mg of hydralazine hydrochloride, 1.5 mg of hydrochlorothiazide, 0.025 mg of cyclopenthiazide, 2 mg of promethazine hydrochloride, 1 mg of vitamin B1, 1 mg of vitamin B6, 5 mg of rutin, 30 mg of potassium chloride, and 2.5 mg of chloroquine phosphate.
Manufacturer	Henan Zhongjie Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Zhengzhou Taifeng Pharmaceutical Co., Ltd.

China
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