(±)-1-Amino-2-propanol

75.11

75.11

605275

201-162-7

0905

3188

2735|1993

DTXSID9021764

LIQUID

29221980

46.2

-1

Clear Liquid

0.9611 g/cm³ @ Temp: 20 °C

1.74 °C

159.46 °C @ Press: 760 Torr

165 °F

1.440

H2O: freely soluble

2-8°C

<1 mm Hg ( 20 °C)

2.6 (vs air)

Oral-rat LD50: 1715mg/kg; Abdominal cavity-mouse LDL0: 250 mg/kg

Near heat, flames, sparks and strong oxidants are flammable; nitrocellulose exposed to large surface area ignites; high heat produces toxic nitrogen oxide fumes

1.9-10.4%(V)

SLIGHT AMMONIA ODOR

MP 156-158 °C @ 758 MM HG; DENSITY 0.973 @ 18 °C; SOL IN ALL PROPORTIONS IN WATER, ALC, ETHER, ACETONE, BENZENE. /L-FORM/

Water soluble.

Alcohols and Polyols

MONOISOPROPANOLAMINE is an aminoalcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

706 °F (USCG, 1999)|705 °F (374 °C)|374 °C

Ⅱ

8

UN 2735 8/PG 2

1

34-21/22

23-26-36-45-36/37

UA5775000

C,Xn

Treasury is ventilated, low temperature and dry; stored separately from oxidant

Stable. Substances to be avoided include strong oxidizing agents. Combustible. Hygroscopic.

P280-P305 + P351 + P338-P310

H302 + H312-H314

Special Hazards of Combustion Products: Irritating vapors generated when heated. (USCG, 1999)|Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Above 77 °C explosive vapour/air mixtures may be formed.|Flammable - 2nd degree

|Danger|H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]|P260, P264, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P363, P405, and P501|H312 (86.08%): Harmful in contact with skin [Warning Acute toxicity, dermal]|P260, P264, P280, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P322, P363, P405, and P501|Aggregated GHS information provided by 3019 companies from 19 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P260, P264, P270, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P363, P405, and P501|H227: Combustible liquid [Warning Flammable liquids]|P210, P260, P264, P280, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P322, P363, P370+P378, P403+P235, P405, and P501

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2016)

Full face shield; goggles; eye wash facility. (USCG, 1999)

Explosive limits , vol% in air: 1.9-10.4

ALCOHOL FOAM

Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Separated from strong oxidants and food and feedstuffs. See Chemical Dangers. Well closed. Keep in a well-ventilated room. Store in an area without drain or sewer access.

No indication can be given whether a harmful concentration in the air will be reached.

The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest. Medical observation is indicated. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis.

Repeated or prolonged contact with skin may cause dermatitis.

NO open flames. Above 77 °C use a closed system and ventilation.

AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!

Use ventilation, local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear face shield or eye protection in combination with breathing protection.

| 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury.| 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air.| 0 - Materials that in themselves are normally stable, even under fire conditions.| 3 - Materials that, under emergency conditions, can cause serious or permanent injury.

The major hazards encountered in the use and handling of 1-amino-2-propanol stem from its toxicologic properties. Toxic primarily by inhalation and dermal contact, exposure to this liquid, with a slight ammonia odor, may occur from its production and use as a chemical intermediate, emulsifying agent, in drycleaning soaps, wax removers, metal cutting oils, cosmetics, plasticizers,and insecticides. In activities and situations where over-exposure may occur, wear a self-contained breathing apparatus. If contact should occur, irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes, and wash exposed skin thoroughly with soap and water. 1-Amino-2-propanol must be moderately heated before ignition will occur. Fires involving this substance may be extinguished with water spray or alcohol foam.

moderately toxic

LD50 Rat oral 4.26 g/kg

Since 1-amino-2-propanol is primarily used as a chemical intermediate in the production of derivatives for many industries(1), it may be released to the environment in waste streams generated at sites of its commercial production and use(SRC).

TERRESTRIAL FATE: The dominant degradation process for 1-amino-2-propanol in soil is expected to be biodegradation. Several biodegradation studies have demonstrated that 1-amino-2-propanol is biodegradable(1,2,3). Based upon an estimated Koc of 7.1, 1-amino-2-propanol is expected to leach readily in soil(4,SRC). The importance of leaching may be lessened by concurrent biodegradation. Based upon a vapor pressure of 0.47 mm Hg at 25 °C(5), 1-amino-2-propanol should evaporate slowly from dry surfaces(SRC).|AQUATIC FATE: The dominant removal process for 1-amino-2-propanol in water is expected to be biodegradation. Several biodegradation studies have demonstrated that 1-amino-2-propanol is readily biodegradable(1,2,3). Aquatic volatilization, bioconcentration, and adsorption to sediment are not expected to be important(SRC).|ATMOSPHERIC FATE: Based upon a vapor pressure of 0.47 mm Hg at 25 °C(1), 1-amino-2-propanol is expected to exist almost entirely in the vapor-phase in the ambient atmosphere(2,SRC). It is expected to degrade relatively rapidly in an average ambient atmosphere (estimated half-life of about 9.9 hr) by reaction with photochemically produced hydroxyl radicals (3,SRC). Since 1-amino-2-propanol is miscible in water(4), physical removal via wet deposition is likely to occur(SRC).

The rate constant for the vapor-phase reaction of 1-amino-2-propanol with photochemically produced hydroxyl radicals has been estimated to be 39.1X10-12 cu cm/molecule-sec at room temperature which corresponds to an atmospheric half-life of about 9.9 hr at an atmospheric concn of 5X10+5 hydroxyl radicals per cu cm(1,SRC).

Based upon an experimental log Kow of - 0.96(1), the BCF for 1-amino-2-propanol can be estimated to be 0.11 from a regression-derived equation(2,SRC). This BCF value suggests that 1-amino-2-propanol will not bioconcentrate significantly in aquatic organisms(SRC).

Based upon an experimental log Kow of -0.96(1), the Koc for 1-amino-2-propanol can be estimated to be 7.1 from a regression-derived equation(2,SRC). This BCF value suggests that 1-amino-2-propanol has very high soil mobility(3).

The Henry's Law constant for 1-amino-2-propanol can be estimated to be 2.34X10-10 atm-cu m/mole using a structure estimation method(1,SRC); this value of Henry's Law constant indicates that a compound is essentially non-volatile from water(2). Based upon a vapor pressure of 0.47 mm Hg at 25 °C(3), 1-amino-2-propanol should evaporate from dry surfaces(SRC).

Occupational exposure to 1-amino-2-propa dermal contact and inhalation of vapo relatively low vapor A10: 19 (1987) Occu dermal contact and inhalation of vapo relatively low vapor|NIOSH (NOES Survey 1981-1983) has statistically estimated that 99,320 workers are potentially exposed to 1-amino-2-propanol in the USA(1).

Vapor irritates eyes and nose. Liquid causes local injury to mouth, throat, digestive tract, skin, and eyes. (USCG, 1999)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.

First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Refer for medical attention .

Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer immediately for medical attention.

1-amino-2-propanol

Serious local effects by all routes of exposure.

Sore throat. Cough. Burning sensation. Shortness of breath. Laboured breathing.

Pain. Redness. Blisters. Skin burns.

Pain. Redness. Severe burns. Loss of vision.

All other chemical product and preparation manufacturing|2-Propanol, 1-amino-: ACTIVE

Of 75 organic compounds listed in Appendix D to 40 CFR 122, 24 compounds have not been previously shown amenable to existing EPA Methods for analysis in water and wastewater. The present work reports on 17 of those 24 compounds using 600 Methods with appropriate modification. The approach was to demonstrate performance in the areas: (1) chromatography - using fused silica capillary columns, (2) extraction and concentration, and (3) cleanup. When attempts were successful, the integrated method was tested for accuracy and precision. A purge-and-trap approach was shown to have substantial problems with the volatile amines. An automated heated headspace/capillary column method worked poorly for monoalkyl amines. A specially prepared column packing was effective for all of the volatile amines. No method development was achieved for either ethanolamine or isopropanolamine.

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