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Home > Encyclopedia > Copper

Copper

pharmaceutical raw materials
Copper structure

Copper 

structure
  • CAS No:

    7440-50-8

  • Formula:

    Cu

  • Chemical Name:

    Copper

  • Synonyms:

    Copper;C.I. 77400;C.I. Pigment Metal 2;1721 Gold;Raney copper;Arwood copper;Kafar copper;Copper Powder;CuEP;CuEPP;CE 1110;E 115 (metal);E 115;GE 1110;CE 115;Rame;TTAI;Copper element;TAI (metal);MF-DZ;TAI;CE 7 (metal);M 36.012;Nogac 18;CE 7;NDGAC 35;MD 1 (metal);MF-D2;MD 1;C 100 (metal);C 100;JTC 1OZ;HTE;3EC;DN 02;CE 25;CE 15;TSTO 35;200RL;CE 1100;3L Fire;FCC 115A;BSH (metal);BSH;22BB400;CS-F 150E;1100T;MF-D3;OFHC copper;OFHC;3EC-HTE;R 300 (metal);3EC-III;R 300;CF 78;SPC 4-8;BHY 13T;TUP;MA-CDS;3EC3;CE 8A;SQ-HTE;CuLox 6010;CuLox 6030;BHY 02B-T;SLP;Cu-At-W 250;BHN 02T;SRM394;SRM395;M 330;3EC-VLP;FCC 115;JTC;JTC-LP;JTC-AM;JTCS;SFR-Cu;GTS 35;GTS 35 (metal);CF-T 8;CU-FN 10;115A;Allbri Natural Copper;Silcoat FCC-SP 99;NDGC;YGP 35;TSC 35;SLP 18;DT GLMP;M 330 (metal);R 300A;SQ-VLP;CT 315E;CDX;CDX (metal);FCC-SP 99;Unicoat 2845;DP 3;DP 3 (metal);MFP-CU 125;BHY 22B-T;FX-BSH;100RXH;F 2WS;CU 112;2L3GT;BPF 18;NT-TAX-M;NT-TAX-O;GT;GT (metal);GT-MP;SFR-Cu 5;SFR-Cu 10;Cu-HWQ;MFP 1110;GTS 18;BHY 13HT;F 1WS;HCCD 101;XMCu;GTS 12;Micro Thin;GTS;GTS (element);GT-MP 35;CCL-HL 830;F 3B-WS;BHN;USLP 12;F 0WS;Double Thin F-NP;BAC 13B-NK120;3EC-VEP;FQ-VLP;B152-ETP;UCP 030;EFC 6000;SLP 105WB;CE 6;YB 10;Y 10 (metal);F 3WS18;Y 10;CE 6 (copper);F 2WS18;MC 2;MC 2 (metal);USLP-R 2;N 254Di;FGP;CF-T 9;MA-CD;TSTO;1300YM;XTF;F-CP;SLP 100;3EC-VLP35;BAC 13T;AM-FN;B-WS;3EC-VLP18;FCC 116;TQ-VLP;CF-T 9-18;CF-T 9B-THE;65555-90-0;72514-83-1;133353-46-5;133353-47-6;195161-80-9;1441640-38-5;1993435-25-8;2056901-56-3;2432029-48-4

  • Categories:

    Cosmetic Ingredient  >  Cosmetic Colorant

Description

Reddish brown metal; face-centered cubic crystal; density 8.92 g/cm3; Mohs hardness 2.5 to 3.0; Brinnel hardness 43 (annealed); electrical resistivity 1.71 microhm-cm at 25°C; Poisson's ratio 0.33; melts at 1,083°C; vaporizes at 2,567°C; insoluble in water; dissolves in nitric acid and hot sulfuric acid; slightly soluble in hydrochloric acid; also soluble in ammonium hydroxide, ammonium carbonate and potassium cyanide solutions. Copper is a reddish-brown metal which occurs free or in ores, su


Reddish lustrous malleable odorless metallic solid.|DryPowder; DryPowder, OtherSolid; DryPowder, PelletsLargeCrystals, WetSolid; DryPowder, WetSolid; Liquid; OtherSolid; OtherSolid, Liquid; PelletsLargeCrystals; PelletsLargeCrystals, OtherSolid|SOLID IN VARIOUS FORMS. TURNS GREEN ON EXPOSURE TO MOIST AIR.|Reddish, lustrous, malleable, odorless solid.


Reddish lustrous malleable odorless metallic solid.|Copper is a metal that occurs naturally throughout the environment, in rocks, soil, water, and air. Copper is an essential element in plants and animals (including humans), which means it is necessary for us to live. Therefore, plants and animals must absorb some copper from eating, drinking, and breathing.Copper is used to make many different kinds of products like wire, plumbing pipes, and sheet metal. U.S. pennies made before 1982 are made of copper, while those made after 1982 are only coated with copper. Copper is also combined with other metals to make brass and bronze pipes and faucets.Copper compounds are commonly used in agriculture to treat plant diseases like mildew, for water treatment and, as preservatives for wood, leather, and fabrics.|Copper atom is a copper group element atom and a metal allergen. It has a role as a micronutrient and an Escherichia coli metabolite.|Copper is a transition metal and a trace element in the body. It is important to the function of many enzymes including cytochrome c oxidase, monoamine oxidase and superoxide dismutase. Copper is commonly used in contraceptive intrauterine devices (IUD).|Copper is an essential trace element that is included in some over-the-counter multivitamin and mineral supplements, even though copper deficiency is quite rare and supplementation is rarely needed. The amounts of copper found in typical supplements has not been associated with serum enzyme elevations or with clinically apparent liver injury. However, accidental or intentional copper overdose can cause an acute liver injury and chronic ingestion of excessive amounts of copper can result in copper overload and chronic liver injury.|Copper is an element with atomic symbol Cu, atomic number 29, and atomic weight 63.|A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.

Copper Basic Attributes

63.54600

62.92960

231-159-6

789U1901C5

0240

3089|3077

DTXSID2023985

C391

Reddish, lustrous, ductile, malleable metal|Red metal; cubic

7402000090

Characteristics

0

-0.00250

Reddish lustrous malleable odorless metallic solid.

8.94 g/cm3

1083 °C

2595 °C

-23ºC

Insoluble

2-8ºC

0 mmHg (approx)

LD50 intraperitoneal in mouse: 3500ug/kg

Noncombustible Solid in bulk form, but powdered form may ignite.

Odorless /Copper dusts and mists/

Lustrous, ductile, malleable metal; Mohs' hardness: 3.0; specific resistance: 1.673 microohm/cm; heat of fusion: 48.9 cal/g; heat capacity (solid): 0.092 cal/g/deg C at 20 °C, (liq): 0.112 cal/g/deg C; becomes dull when exposed to air; two naturally occurring isotopes: 63 (69.09%), 65 (30.91%); 9 artificial isotopes|Very slowly attacked by cold hydrochloric acid or dil sulfuric acid; readily by dil nitric acid, and by both not conch sulfuric acid and hydrobromic acid. It is also attacked by acetic acid and other organic acids.|COPPER FORMS TWO SERIES OF SALTS, CU(1+) AND CU(2+) BOTH VALENCE TYPES FORM COMPLEX IONS THAT ARE STABLE.|Ductile, excellent conductor of electricity. Complexing agent, coordination numbers 2 and 4. More resistant to atmospheric corrosion than iron, forming green layer of hydrated basic carbonate. Readily attacked by alkalies. Noncombustible, except as powder.|For more Other Experimental Properties (Complete) data for COPPER, ELEMENTAL (6 total), please visit the HSDB record page.

Solid pieces are very slowly oxidized by air to give a green basic carbonate. Solid pieces become covered by a black oxide when heated in air. Insoluble in water.

Metals, Less Reactive

COPPER combines violently with chlorine trifluoride in the presence of carbon [Mellor 2, Supp. 1, 1956]. Is oxidized by sodium peroxide with incandescence [Mellor 2:490-93, 1946-1947]. Forms an unstable acetylide when acetylene is passed over samples that have been heated enough to form an oxide coating. Reacts more rapidly in powdered or granular form. Subject to explosive reaction then mixed in finely divided form with finely divided bromates chlorates and iodates of barium, calcium, magnesium, potassium, sodium, or zinc; these reactions are initiated by heat, percussion, and occasionally light friction [Mellor 2:310, 1946-1947]. A solution of sodium azide in copper pipe with lead joints formed copper azide and lead azide, both of these compounds can detonate [Klotz, 1973].

Noncombustible Solid in bulk form, but powdered form may ignite.

1150 cal/g

Safety Information

III

4.1

UN 1325/1587/3089

3

R11

S16

GL5325000

F

See Chemical Dangers.

Stable. Incompatible with strong acids, active halogen compounds, chlorine, fluorine, iodine, bromine, ammonia. May react explosively with strong oxidizing agents.

P210-P273

H228-H410

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.|Alternative treatment processes for metal bearing hazardous waste streams are reviewed. Precipitation is the preferred treatment process for removing toxic heavy metals from electroplating waters. Precipitation processes include hydroxide, lime and/or sulfide treatment. Chemical reduction is used to treat complex metals such as nickel, copper, hexavalent chromium waste, soluble lead, silver, metal containing cyanide, and mercury. Adsorption has shown potential for treating and polishing aqueous metal bearing wastes. Activated carbon, activated alumina, and iron filings are all applicable adsorbents. Alkaline chlorination and incineration are effective cyanide destruction treatments. Evaporation, ion exchange, reverse osmosis, electrodialysis, and electrolytic recovery are waste reduction and recovery techniques applicable to metal bearing hazardous streams.|COPPER DUSTS OR MIST AND COPPER CMPD MAY BE DISPOSED OF IN SEALED CONTAINERS IN A SECURED SANITARY LANDFILL. /COPPER DUSTS & MISTS/

Reacts violently with ... ammonium nitrate, bromates, chlorates, iodates, chloride, ... ethylene oxide, ... hydrazine mononitrate, hydrazoic acid, ... and potassium oxide ... .|A combination of finely divided copper with finely divided bromates (also chlorates or iodates) of barium, calcium, magnesium, potassium, sodium, or zinc will explode with heat, percussion and sometimes light friction.|Unstable acetylides form when acetylene is passed over copper that has been heated enough to form a tarnish of oxide coating.|SODIUM AZIDE ... REACTS VIOLENTLY WITH ... COPPER ... .|For more Hazardous Reactivities and Incompatibilities (Complete) data for COPPER, ELEMENTAL (6 total), please visit the HSDB record page.

Certification of this color additive when used in coloring externally applied drugs, including those intended for use in the area of the eye, in amounts consistent with good manufacturing practice is not necessary for the protection of the public health, and therefore batches thereof are exempt from the certification pursuant to section 721(c) of the act. /Copper powder/

NAS; Medical and Biologic Effects of Environmental Pollutants Copper (1974)|USEPA; Ambient Water Quality Criteria Doc: Copper (1980) EPA 440/5-80-036.|USEPA; Health Issue Assessment: Copper (1987) EPA/600/8-87/001.|USEPA; Drinking Water Criteria Document for Copper (Final Draft) (1985) EPA-600/X-84-190-1|For more Special Reports (Complete) data for COPPER, ELEMENTAL (6 total), please visit the HSDB record page.

Combustible. Finely dispersed particles form explosive mixtures in air.

|Danger|H302 (52.49%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P273, P280, P301+P312, P304+P340, P305+P351+P338, P311, P321, P330, P337+P313, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 3454 companies from 65 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H317: May cause an allergic skin reaction [Warning Sensitization, Skin]|P260, P261, P264, P270, P271, P272, P280, P302+P352, P304+P340, P307+P311, P312, P321, P333+P313, P363, P403+P233, P405, and P501|H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]|P260, P261, P264, P270, P271, P304+P340, P312, P314, P403+P233, P405, and P501

Use special powder, dry sand. NO other agents. Water may be ineffective.

Skin: Wear appropriate personal protective clothing to prevent skin contact. Eyes: Wear appropriate eye protection to prevent eye contact. Wash skin: The worker should immediately wash the skin when it becomes contaminated. Remove: Work clothing that becomes wet or significantly contaminated should be removed and replaced. Change: Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premise. (NIOSH, 2016)|Copper miners generally wear filtering masks when exposed to dusts from copper ores. The main purpose ... is the retention of free silica in the atmosphere; however, such masks also minimize the inhalation of copper.|For copper dusts or mists: Wear appropriate clothing to prevent repeated or prolonged skin contact. Wear eye protection to prevent any reasonable probability of eye contact. /Copper dusts or mists/|Wear appropriate personal protective clothing to prevent skin contact. /Copper dusts and mists/|Wear appropriate eye protection to prevent eye contact. /Copper dusts and mists/|For more Personal Protective Equipment (PPE) (Complete) data for COPPER, ELEMENTAL (11 total), please visit the HSDB record page.|(See protection codes)

1. VENTILATE AREA OF RELEASE. 2. COLLECT SPILLED MATERIAL IN THE MOST CONVENIENT AND SAFE MANNER FOR RECLAMATION, OR FOR DISPOSAL IN A SECURE SANITARY LANDFILL. LIQ CONTAINING COPPER SHOULD BE ABSORBED IN VERMICULITE, DRY SAND, EARTH, OR A SIMILAR MATERIAL. /COPPER DUSTS & MISTS/

The prevention of metal fume fever is a matter of keeping exposure below the level of concn currently accepted as satisfactory for working with copper in industry. The employment of local exhaust ventilation is a necessary measure to collect fumes at their source.|SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.|The major hazards are exposure to ore dusts during ore processing & smelting, metal fumes ... during smelting, sulfur dioxide & carbon monoxide during most smelting operations, ...& sulfuric acid & electrical hazards during electrolytic processes. Precautions include: local exhaust ventilation (LEV) for dusts during transfer operations; local exhaust & dilution ventilation for sulfur dioxide & carbon monoxide; ... protective clothing and shields... . Respiratory protection is commonly worn to protect against dusts, fumes & sulfur dioxide.|Employees should wash promptly when skin is contaminated. Work clothing should be changed daily if clothing is contaminated. Remove nonimpervious clothing promptly if contaminated. /Copper and compounds/|For more Preventive Measures (Complete) data for COPPER, ELEMENTAL (8 total), please visit the HSDB record page.

The fumes and dust cause irritation of the upper respiratory tract.|Inhalation of copper fume results in the irritation of the upper respiratory tract. ... Contact with copper fumes will also cause irritation of the eyes, nose and throat. /Copper fumes/|Copper or copper salts may induce allergic contact dermatitis in susceptible individuals. Signs & symptoms include itching, redness, swelling, vesicle formation & pustulation. /Copper or copper salts/

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 1 mg/cu m. /Copper (dusts and mists)/

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. Carefully collect remainder. Then store and dispose of according to local regulations.

See Chemical Dangers.

A harmful concentration of airborne particles can be reached quickly when dispersed.

Inhalation of fumes may cause metal fume fever.

Repeated or prolonged contact may cause skin sensitization. Ingestion may cause effects on the liver.

NO open flames.

PREVENT DISPERSION OF DUST!

Use local exhaust or breathing protection.

Protective gloves.

Wear safety goggles.

... Substances for which a Federal Register notice has been published that included consideration of the serious health effects, including cancer, from ambient air exposure to the substance. Copper (52 FR 5496; Feb 23, 1987) is included on this list.

Copper is a metal that occurs naturally throughout the environment, in rocks, soil, water, and air. Copper is an essential element in plants and animals (including humans), which means it is necessary for us to live. Therefore, plants and animals must absorb some copper from eating, drinking, and breathing.Copper is used to make many different kinds of products like wire, plumbing pipes, and sheet metal. U.S. pennies made before 1982 are made of copper, while those made after 1982 are only coated with copper. Copper is also combined with other metals to make brass and bronze pipes and faucets.Copper compounds are commonly used in agriculture to treat plant diseases like mildew, for water treatment and, as preservatives for wood, leather, and fabrics.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 5000 lb or 2270 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

Toxicity

Copper toxicity is belevied to be due to fenton-type redox reactions occuring with high copper concentrations which produce damaging reactive oxygen species.

Acute hepatotoxicity of copper is usually the result of ingestion of toxic amounts (1 to 10 g), often as a suicide attempt. In children, accidental poisoning can occur, particularly with ingestion of coins. Initial symptoms may be metallic taste and gastrointestinal distress due to gastric or small bowel erosions. Acute overdoses of copper can lead to early appearance of cardiovascular collapse, coma and death within hours. Liver injury tends to arise after 24 to 72 hours and is characterized by marked elevations in serum aminotransferase levels, minimal increases in alkaline phosphatase, early appearance of hepatic failure, and elevation in prothrombin time and ensuing jaundice. Shock and renal failure may also be present as well as rhabdomyolysis and severe hemolytic anemia. The overall clinical pattern of the liver injury is that of acute hepatic necrosis, and the hepatic manifestations resemble the acute toxicity of iron and zinc, and can be reproduced in animals. Shock and rhabdomyolysis may contribute to the serum enzyme elevations while hemolytic anemia may account for some of the increase in total bilirubin levels. Therapy of copper overdose includes gastric lavage, fluid replacement, dimercaprol (BAL) and penicillamine, with blood transfusions for hemolytic anemia and dialysis for acute renal failure.

Persons at special risk include those with impaired pulmonary function, especially those with obstructive airway diseases, since the breathing of copper fume might cause exacerbation of symptoms due to its irritant properties. /Copper fume/

Copper is nearly entirely bound by ceruloplasmin (65-90%), plasma albumin (18%), and alpha 2-macroglobulin (12%).

Occurrence /all forms/ in earth's crust: 70 ppm ... in seawater: 0.001-0.02 ppm. ... found in nature in its native state; also in combined form in several minerals incl chalcopyrite, chalcocite, bornite, tetrahedrite ... enargite ... antlerite.|Copper is present in concn averaging about 4 ppm in limestones, 55 ppm in igneous rocks, 50 ppm in sandstones, and 45 ppm in shales. The marked concentrations of copper in shales & sandstones suggest that copper in the lithosphere exists largely as adsorbed ions, fine grained particles or as one of many discrete sedimentary copper minerals. Generally, these minerals occur only as sparse tiny grains that are widely disseminated throughout the sedimentary rocks.

... IN THE VICINITY OF COPPER MINES OR SMELTING WORKS, WHERE THE WATER AND PASTURE HAVE BEEN SHOWN TO BE CONTAMINATED WITH COPPER.|Smelting operations may produce ... elemental copper ... /and/ it is likely that municipal incineration will produce copper ... .

Terrestrial Fate: The fate of copper with respect to its leachability in purely organic spruce forest soils was studied. Appreciable mobilization of copper occurred only with prolonged leaching at pH 2.8. Therefore, it does not appear likely that acidic rainfall will result in significant mobilization of copper from organic soils unless the pH of rainfall decreases to < 3. ... Estimated that approx 50% of copper in the top few centimeters of these soils was organically bound, approx 18% was in the hydroxy carbonate form, approx 7% was in the adsorbed state, approx 11% was bound by other anions and 6% was irreversibly adsorbed. Only 3% of the copper was extractable with water at pH 4.5; hence only 3% was mobile at this pH. ... In urbanized areas the effects of land clearing, profile disruption and increased acid rainfall may increase copper mobilization in these soils.

A study was conducted on the distribution of managanese, iron, copper, lead, and zinc in the water and sediment of Kelang esturary in 1981. The mean total levels of manganese, iron, copper, lead, and zinc in the estuarine water were 27.1 ug/l, 106.5 g/l, 10.0 ug/l, 4.1 ug/l and 17.9 ug/l respectively. The results indicate that Kelang estuary is polluted with lead, manganese, and iron. However, levels of these heavy metals may still be considered safe for aquaculture, if the farm is located at least 10 km away from the river mouth.

Copper dissolved from the wire used in certain intrauterine contraceptive devices has been shown to be absorbed systemically. An appreciable fraction of the copper dissolved from the tubing commonly used in hemodialysis equipment may be retained by the patient ... .|STUDY OF THE LITERATURE DESCRIBING SYMPTOMS OCCASIONALLY OBSERVED IN COPPER & BRASS WORKERS WORKERS DOES NOT ALLOW ONE TO CONCLUDE THAT COPPER INTOXICATION IS OCCUPATIONAL DISEASE. SUCH SYMPTOMS ARE DUE TO POOR WORKING CONDITIONS, PRESENCE OF ARSENIC & LEAD AS IMPURITIES ... .|Copper bracelets are worn as a folk remedy for rheumatic disorders; there is no good evidence to justify such a practice.

Drug Information

For use in the supplementation of total parenteral nutrition and in contraception with intrauterine devices.|FDA Label

Copper is an essential trace element that is included in some over-the-counter multivitamin and mineral supplements, even though copper deficiency is quite rare and supplementation is rarely needed. The amounts of copper found in typical supplements has not been associated with serum enzyme elevations or with clinically apparent liver injury. However, accidental or intentional copper overdose can cause an acute liver injury and chronic ingestion of excessive amounts of copper can result in copper overload and chronic liver injury.

Trace Elements and Metals

Copper has a contraceptive effect when present in the uterus. It is added to some intrauterine contraceptive devices permitting reduction in their size with concomitant reduction in the associated side effects such as pain and bleeding.

Copper is incorporated into many enzymes throughout the body as an essential part of their function. Copper ions are known to reduce fertility when released from copper-containing IUDs.

A group of chemical elements that are needed in minute quantities for the proper growth, development, and physiology of an organism. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) (See all compounds classified as Trace Elements.)

Copper absorption varies inversely with intake. Absorption range is 12-65%.|Copper appears to be eliminated primarily through bile.|Small fragments of copper ... in the anterior vitreous just behind the lens in a number of cases have been observed for years, gradually dissolving & disseminating copper to lens, cornea & iris, where copper has a predilection for the basement membranes.|Copper dissolved from the wire used in certain intrauterine contraceptive devices has been shown to be absorbed systemically.|... Intrauterine devices containing metallic copper ... raise the endometrial copper concentration 2 fold, & this copper excess might be transferred to the fetus.|Circadian rhythms in the urinary excretion of eleven heavy metals and organic substances were examined under free, water restrictive and water loading conditions for 6 days (2 days for each of the three conditions) in twenty metal workers exposed to lead, zinc, and copper. Circadian rhythms were found for all heavy metals and organic substances as well as for urinary flow rate, creatinine and total urinary solutes. The rhythm in the copper excretion depends on the creatinine rhythm, ie the rhythm of glomerular filtration.|For more Absorption, Distribution and Excretion (Complete) data for COPPER, ELEMENTAL (6 total), please visit the HSDB record page.

Copper is absorbed from the gut via high affinity copper uptake protein and likely through low affinity copper uptake protein and natural resistance-associated macrophage protein-2. It is believed that copper is reduced to the Cu1+ form prior to transport. Once inside the enterocyte, it is bound to copper transport protein ATOX1 which shuttles the ion to copper transporting ATPase-1 on the golgi membrane which take up copper into the golgi apparatus. Once copper has been secreted by enterocytes into the systemic circulation it remain largely bound by ceruloplasmin (65-90%), albumin (18%), and alpha 2-macroglobulin (12%). Copper is an essential element in the body and is incorporated into many oxidase enzymes as a cofactor. It is also a component of zinc/copper super oxide dismutase, giving it an anti-oxidant role. Copper defiency occurs in Occipital Horn Syndrome and Menke's disease both of which are associated with impaired development of connective tissue due to the lack of copper to act as a cofactor in protein-lysine-6-oxidase. Menke's disease is also associated with progressive neurological impairment leading to death in infancy. The precise mechanisms of the effects of copper deficiency are vague due to the wide range of enzymes which use the ion as a cofactor. Copper appears to reduce the viabilty and motility of spermatozoa. This reduces the likelyhood of fertilization with a copper IUD, producing copper's contraceptive effect. The exact mechanism of copper's effect on sperm are unknown.|The reason for the less severe reaction when the foreign body is at a distance from the retina has been proposed to be ... that near the retina & its blood vessels there is greater oxygen tension than at a distance, which causes metallic copper to oxidize to toxic copper compounds more rapidly close to or in contact with the retina than at a distance. Furthermore, the abscess formation that is characteristic of copper undergoing oxidation close to the retina & choroiod can be attributed to attraction of polymorphonuclear leukocytes from these nearby vascular tissues, which become heavily infiltrated. Liquefaction & disorganization of the vitreous body has been explained on the basis of copper catalysis of oxidation of ascorbic acid, leading to depolymerization of the hyaluronic acid of the vitreous humor. Changes in protein & hexosamine content have also been related to decrease in viscosity of the vitreous humor. Increased content of amino acids in the vitreous humor has been consistent with proteolysis of the vitreous body, but decreased concentration in the aqueous humor has suggested suppression of secretion of amino acids by the ciliary body under the influence of copper.

/In electrolytic copper/ the highest level of impurities other than oxygen are found only to the extent of 15-30 ppm. Up to 0.05% oxygen is present in the form of copper(I) oxide.|Average impurity levels: Antimony, 3.41 ppm; arsenic, 1.39 ppm; bismuth, 0.36 ppm; iron, 6.07 ppm; lead, 4.08 ppm; oxygen 327.25 ppm; nickel, 3.41 ppm; selenium, 1.10 ppm; silver, 11.19 ppm; sulfur, 10.00 ppm; tellurium, 1.16 ppm; tin, 1.63 ppm.

Exposure Routes: inhalation, ingestion, skin and/or eye contact Symptoms: Irritation eyes, respiratory system; cough, dyspnea (breathing difficulty), wheezing; [potential occupational carcinogen] Target Organs: Eyes, skin, respiratory system, liver, kidneys (increase(d) risk with Wilson's disease) (NIOSH, 2016)

Eye: If this chemical contacts the eyes, immediately wash the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Contact lenses should not be worn when working with this chemical. Skin: If this chemical contacts the skin, promptly wash the contaminated skin with soap and water. If this chemical penetrates the clothing, promptly remove the clothing and wash the skin with soap and water. Get medical attention promptly. Breathing: If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform mouth-to-mouth resuscitation. Keep the affected person warm and at rest. Get medical attention as soon as possible. Swallow: If this chemical has been swallowed, get medical attention immediately. (NIOSH, 2016)|(See procedures)


Fresh air, rest. Refer for medical attention.


Remove contaminated clothes. Rinse and then wash skin with water and soap.


Rinse with plenty of water (remove contact lenses if easily possible).

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Copper and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious. Start an IV with lactated Ringer's /SRP: "To keep open", minimal flow rate/. Watch for signs of fluid overload. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine, hydrochloride to assist eye irrigation ... . /Copper and related compounds/

COPPER ITSELF PROBABLY HAS LITTLE OR NO TOXICITY, ALTHOUGH THERE ARE CONFLICTING REPORTS IN LITERATURE.|The fumes and dust cause irritation of the upper respiratory tract.|Inhalation of dusts & fumes of metallic copper ... causes congestion of nasal mucous membranes, ulceration & perforation of the nasal septum, & pharyngeal congestion.|Fumes from the heating of metallic copper can cause metal fume fever, nausea, gastric pain, & diarrhea.|For more Human Toxicity Excerpts (Complete) data for COPPER, ELEMENTAL (37 total), please visit the HSDB record page.

Copper

The substance can be absorbed into the body by inhalation and by ingestion.|inhalation, ingestion, skin and/or eye contact

irritation eyes, nose, pharynx; nasal septum perforation; metallic taste; dermatitis; In Animals: lung, liver, kidney damage; anemia


Cough. Headache. Shortness of breath. Sore throat.


Redness.


Redness. Pain.

Gastrointestinal (Digestive)|Eyes, skin, respiratory system, liver, kidneys (increased risk with Wilson's disease)

Copper Use and Manufacturing

Methods of Manufacturing

CRUSH, GRIND, AND CONCENTRATE COPPER ORES BY FLOTATION (SULFIDE ORES) OR LEACHING WITH ACID (OXIDE ORES); SMELT CONCENTRATES TO YIELD A BLISTER COPPER WHICH IS REFINED ELECTROLYTICALLY OR FIRE REFINED|About 80% of the primary copper in the world comes from low-grade or poor sulfide ores, which are usually treated by pyrometallurgical methods, generally in the following sequence: (1) Beneficiation by froth flotation of ore to copper concentrate; (2) Optional partial roasting to obtain oxidized material or calcines; (3) two-stage pyrometallurgical extraction, (a) smelting concentrates to matte, (b) converting matte by oxidation to crude (converter or blister) copper; (4) Refining the crude copper, usually in two steps, (a) pyrometallurgically to fire-refined copper, (b) electrolytically to high-purity electrolytic copper.|Most copper is processed using a combination of mining, concentrating, smelting, and refining, or by leaching waste and solvent extraction-electrowinning...|Copper, blister (electrolysis); copper oxide ores + iron (acid leaching/cementation); copper oxide ores + sulphuric acid (acid leaching/electrolysis); copper sulphide ores (heap leaching/cementation); copper sulphide ores (heap leaching/electrolysis); copper-cobalt sulphide ores (ore roasting/ acid leaching/electrolysis); lead bullion (pyrometallurgical refining/Parkes process/Betterton-Kroll process; byproduct of lead production)|Copper + chlorine (reaction); copper hydroxide/cupric oxide/copper carbonate basic + hydrochloric acid (salt formation)

Uses

It is a material used in the electronics industry and used as a high-purity analytical reagent. Used in powder metallurgy parts, diamond saw blades, friction materials, electric carbon products and chemical catalysts, etc.; used as analytical reagents, catalysts, and reducing agents; used as ordinary reagents, catalysts and reducing agents; mainly used as raw materials in the copper smelting industry Used as a raw material for smelting and electrolytic copper; mainly used to make conductive equipment and alloys (bronze, brass, cupronickel, etc.); used as a reducing agent for teaching reagents; copper salt preparation; catalyst (powder); alloy; electroplating; reagent , Alloy, electroplating.


A component of aluminum alloy


Adhesives and sealants

Production

1,000,000,000 - 5,000,000,000 lb|(1978) 2.70X10+12 G|(1982) 2.41X10+12 G|(1986) 3.17X10+12 g|Total refined production (1998): 2,490,000 metric tons.

ELECTRICAL & ELECTRONIC PRODUCTS, 54%; BUILDING CONSTRUCTION, 20%; INDUSTRIAL MACHINERY & EQUIPMENT, 13%; TRANSPORTATION, 8%; OTHER (EG, CONSUMER & GENERAL PRODUCTS, CHEM INT), 5% (1982)|Industrial Sector: Building construction, 43%; electrical and electronic products, 24%; industrial machinery and equipment, 13%; transportation, 10%; and consumer and general products, 10% (1986).|Wire mill products accounted for about 49%; brass mill products 46%; foundry powder products 5%.|Building construction 41.4%; electric and electronic products 26.0%; industrial machinery 11.2%; transportation equipment 12.4%; consumer and general products 9.0%

USEPA/OPP Pesticide Code 022501; Trade Names: Allbrinatural copper; ANAC 110; Bronze powder; Cathode copper; Copper bronze; Copper M1; CDA 102; CDA 122; and Copper.|Commercial copper (Cu) is available in six general types: Electrolytic tough-pitch, 99.90% Cu; Deoxidized, 99.90% Cu; Oxygen-free, 99.92% Cu; Silver-bearing, 99.90% Cu; Arsenical, 99.68%; Free-cutting, 99.4-99.5%|Forms available: ingots, sheet, rod, wire, tubing, shot, powder; high purity (impurities less than 10 ppm) as single crystals or whiskers.

Aerospace Manufacturing|Copper: ACTIVE

EPA Method 7210: Copper (Atomic Absorption, Direct Aspiration) Method 7210 is applicable for the determination of metals in solution by atomic absorption spectrometry. Preliminary treatment of wastewater, ground water, EP extracts, and industrial waste is always necessary because of the complexity and variability of sample matrix. After aspiration and atomization of the sample in a flame, a light beam from a hollow cathode lamp or an electrodeless discharge lamp is directed through the flame into a monochromator and onto a detector that measures the amount of light absorbed. ... The light energy absorbed by the flame is a measure of the concentration of that metal in the sample. The performance characteristics for an aqueous sample free of interferences are: a sensitivity of 0.1 mg/l, a detection limit of 0.02 mg/l, and an optimum concentration range 0.2-5 mg/l with wavelength of 324.7 nm. /Total copper/|OSW Method OSW-A, Methodology for the Determination of Metals Emissions in Exhaust Gases from Hazardous Waste Incineration and Similar Combustion Processes. This method is applicable to the sampling and analysis of metals in stack emissions from incinerators and combustors. Detection limit= 6 ng/ml.|APHA Method 3113-B. Metals in Water by Electrothermal Atomic Absorption Spectrometry. Detection limit (unspecified).|APHA Method 3111-B,C. Metals by Direct Air-Acetylene Flame Atomic Absorption Spectrometry. This method is applicable to the determination of metals by direct air-acetylene FAAS. Detection limit (unspecified).|For more Analytic Laboratory Methods (Complete) data for COPPER, ELEMENTAL (19 total), please visit the HSDB record page.

Chemical Classes -> Inorganic substances|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Cosmetics -> Cosmetic colorant

Food Contaminant -> METALS;

Computed Properties

Molecular Weight:63.55
Exact Mass:62.929597
Monoisotopic Mass:62.929597
Heavy Atom Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Participate in the formation and activation of enzymes; constitute important carriers and electron transport systems in the body; participate in the synthesis of hormones and vitamins; regulate the level of free radicals

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

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