1-(Chloromethyl)naphthalene
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1-(Chloromethyl)naphthalene
structure -
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CAS No:
86-52-2
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Formula:
C11H9Cl
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Chemical Name:
1-(Chloromethyl)naphthalene
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Synonyms:
Naphthalene,1-(chloromethyl)-;1-(Chloromethyl)naphthalene;α-(Chloromethyl)naphthalene;1-Naphthylmethyl chloride;α-Naphthylmethyl chloride;1-Naphthalenylmethyl chloride;NSC 8473;1-Naphthalylmethyl chloride;1-(Chloromethyl)naphthalen
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CAS No:
Description
Solid
1-(Chloromethyl)naphthalene is used in the identification of Novel p38α MAP Kinase Inhibitors. It is also used in the Identification of 1,5-Naphthyridine derivatives as a novel series of potent and selective TGF-β type I receptor inhibitors.
1-(Chloromethyl)naphthalene Basic Attributes
176.64
176.64
636885
201-678-2
KD3RZ3R8C4
8473
DTXSID5058939
29036990
Characteristics
0
3.7
deep brown Liquid After Melting
1.174 g/cm3 @ Temp: 20 °C
32 °C
291.5 °C
>230 °F
1.631
Insoluble in water.
Refrigerator
Oral-Rat LD50: 890/kg; Skin-rat LD50:> 5000mg/kg
Flammable, decomposes toxic chloride gas when burning
Safety Information
Ⅱ
8
UN 3261 8/PG 2
3
21/22-34-36/37/38-36-20/21/22
26-36/37/39-45-60-20-27
QJ2800000
C,Xn
Warehouse low temperature, ventilated, dry
Stable at room temperature in closed containers under normal storage and handling conditions.
P280-P305 + P351 + P338-P310
H302-H312-H314
UN 3261 8
|Danger|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P260, P264, P270, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P363, P405, and P501|Aggregated GHS information provided by 56 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
1-(Chloromethyl)naphthalene Use and Manufacturing
From naphthalene chloromethylation system. Heat the naphthalene, polyoxymethylene, glacial acetic acid, 85% phosphoric acid and concentrated hydrochloric acid to 85°C and stir vigorously for 6 hours. After the reaction was completed, it was cooled to 15°C and washed with water. Finally, wash with 10% potassium carbonate solution, separate the water layer, add ether, and dry with anhydrous sodium carbonate. Then the ether is evaporated under normal pressure, the remainder is distilled under reduced pressure, and the fraction at 128-135°C (0.67kPa) is collected to obtain the finished product. In addition, 1-methylnaphthalene chlorination can also produce the product.
Used in synthetic resin, medicine, etc.
Naphthalene, 1-(chloromethyl)-: ACTIVE
Computed Properties
Molecular Weight:176.64
XLogP3:3.7
Rotatable Bond Count:1
Exact Mass:176.0392780
Monoisotopic Mass:176.0392780
Heavy Atom Count:12
Complexity:144
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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