2-sec-Butylphenol

150.21800

150.22

201-933-8

1472

3145|1760

DTXSID2022331

LIQUID|Amber-colored liquid|Colorless liquid or solid (below 61 degrees F).

2907191090

20.23000

2.90570

O-sec-butylphenol is a clear colorless liquid. (NTP, 1992)

98.04 g/cm³ @ Temp: 25 °C

14 °C

224-237 °C

234 °F

n20/D 1.522(lit.)

Insoluble. <0.1 g/100 mL at 20 ºC

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Corrosives area.

0.03 mm Hg ( 20 °C)

5.2

Class IIB Combustible Liquid Combustible Solid

Flash pt = 225 °F; a slightly volatile liquid

Insoluble in water.

Phenols and Cresols

Phenols, such as O-SEC-BUTYLPHENOL, do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has pKa = 9.88). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Such heating may initiate polymerization of the organic compound. Phenols are sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid.

Class IIB Combustible Liquid Combustible Solid

III

8

UN 3145 8/PG 2

2

R22;R34

S26-S27-S28-S36/37/39-S45

SJ8920000

C:Corrosive;

Separated from acid anhydrides, acid chlorides, bases and food and feedstuffs.

Stable, but air sensitive. Incompatible with acid chlorides, acid anhydrides, bases, strong oxidizing agents, copper and its alloys, brass.

P280-P305 + P351 + P338-P310

H302-H314

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

This chemical is combustible. (NTP, 1992)|Combustible.

|Danger|H302 (89.35%): Harmful if swallowed [Warning Acute toxicity, oral]|P260, P261, P264, P270, P271, P273, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P363, P391, P405, and P501|Aggregated GHS information provided by 314 companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P260, P261, P264, P270, P271, P273, P280, P301+P312, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P330, P363, P391, P403+P233, P405, and P501|P260, P264, P270, P280, P301+P312, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P309+P311, P310, P321, P330, P363, P405, and P501|P260, P261, P264, P270, P271, P280, P301+P312, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P330, P363, P403+P233, P405, and P501

Fires involving this compound should be controlled with a dry chemical, carbon dioxide or halon extinguisher. (NTP, 1992)|Use carbon dioxide, foam, powder.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this material in a refrigerator. (NTP, 1992)

Skin: Wear appropriate personal protective clothing to prevent skin contact. Eyes: Wear appropriate eye protection to prevent eye contact. Wash skin: The worker should immediately wash the skin when it becomes contaminated. Remove: Work clothing that becomes wet or significantly contaminated should be removed and replaced. Change: No recommendation is made specifying the need for the worker to change clothing after the work shift. Provide: Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substance; this is irrespective of the recommendation involving the wearing of eye protection. Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.] (NIOSH, 2016)|Wear appropriate personal protective clothing to prevent skin contact.|Wear appropriate eye protection to prevent eye contact.|Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substance; this is irrespective of the recommendation involving the wearing of eye protection.|Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. (Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.)|(See protection codes)

The worker should immediately wash the skin when it becomes contaminated.|Work clothing that becomes wet or significantly contaminated should be removed and replaced.

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 5 ppm (30 mg/cu m), skin.

Collect leaking and spilled liquid in sealable containers as far as possible. Sweep spilled substance into covered containers. Carefully collect remainder. Then store and dispose of according to local regulations. Personal protection: chemical protection suit.

Separated from acid anhydrides, acid chlorides, bases and food and feedstuffs.

A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20 °C.

The substance is corrosive to the eyes and skin. The vapour is irritating to the respiratory tract. Corrosive on ingestion.

NO open flames.

PREVENT GENERATION OF MISTS! IN ALL CASES CONSULT A DOCTOR!

Use ventilation, local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear face shield.

2-(1-Methylpropyl)phenol's production and use as a chemical intermediate in the preparation of resins, plasticizers, surface-active agents(1) or as an intermediate in the synthesis of insecticides, acaricides, and herbicides(2) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 1400(SRC), determined from an experimental log Kow(2) and a recommended regression-derived equation(3), indicates that 2-(1-methylpropyl)phenol will have low mobility in soil(SRC). Volatilization of 2-(1-methylpropyl)phenol from moist soil surfaces will be slow(SRC) given an estimated Henry's Law constant of 2.1X10-6 atm-cu m/mole(4,SRC). Limited data, mainly derived by analogy to 4-s-butylphenol, indicate that 2-(1-methylpropyl)phenol may be resistant to biodegradation by non-adapted microbial populations(SRC). Resting cells of a Pseudomonas strain obtained by selective enrichment with 4-hydroxybenzoate as the sole carbon source, were able to biodegrade 2-(1-methylpropyl)phenol (oxygen uptake rate of 42 nmol O2/min/mg protein)(5). A structurally similar compound, 4-s-butylphenol (at 100 mg/L) was not biodegraded over a 2 week period using an activated sludge inoculum(6); however, a phenol-adapted yeast strain, isolated from soil, readily oxidized 4-s-butylphenol (present at 1 mmole) without a lag period(7).|AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 1400(SRC), determined from an experimental log Kow(2) and a recommended regression-derived equation(3), indicates that 2-(1-methylpropyl)phenol would adsorb to suspended solids and sediment(SRC) in the water. 2-(1-Methylpropyl)phenol may volatilize from water surfaces based on an estimated Henry's Law constant of 2.1X10-6 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Estimated half-lives for a model river and model lake are 21 and 160 days, respectively(3,SRC). Limited data, mainly derived by analogy to 4-s-butylphenol, indicate that 2-(1-methylpropyl)phenol may be resistant to biodegradation by non-adapted microbial populations(SRC). A 4-hydroxybenzoate adapted Pseudomonas strain was able to biodegrade 2-(1-methylpropyl)phenol (oxygen uptake rate of 42 nmol O2/min/mg protein)(5). A structurally similar compound, 4-s-butylphenol (at 100 mg/L) was not biodegraded over a 2 week period using an activated sludge inoculum(6); however, a phenol-adapted yeast strain, isolated from soil, readily oxidized 4-s-butylphenol (present at 1 mmole) without a lag period(7). An estimated BCF value of 180(3,SRC), determined from an experimental log Kow(2), suggests that 2-(1-methylpropyl)phenol may bioconcentrate in aquatic organisms(SRC) according to a recommended classification scheme(8).|ATMOSPHERIC FATE: According to a suggested classification scheme(1), an estimated vapor pressure of 0.05 mm Hg at 25 °C(2,SRC) indicates that 2-(1-methylpropyl)phenol will exist mainly in the vapor phase in the ambient atmosphere. Vapor-phase 2-(1-methylpropyl)phenol is degraded in the atmosphere by reaction with photochemically produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 9 hours(3,SRC).

The rate constant for the vapor-phase reaction of 2-(1-methylpropyl)phenol with photochemically produced hydroxyl radicals has been estimated as 4.4X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1,SRC). This corresponds to an atmospheric half-life of about 9 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1,SRC).

An estimated BCF value of 180 was calculated for 2-(1-methylpropyl)phenol(SRC), using an experimental log Kow of 3.27(1) and a recommended regression-derived equation(2). According to a recommended classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms may occur(SRC).

The Koc of 2-(1-methylpropyl)phenol is estimated as approximately 1400(SRC), using an experimental log Kow of 3.27(1) and a regression-derived equation(2,SRC). According to a recommended classification scheme(3), this estimated Koc value suggests that 2-(1-methylpropyl)phenol has low mobility in soil(SRC).

The Henry's Law constant for 2-(1-methylpropyl)phenol is estimated as 2.1X10-6 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This value indicates that 2-(1-methylpropyl)phenol will volatilize from water surfaces(2,SRC). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec) is estimated as approximately 21 days(2,SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec) is estimated as approximately 160 days(2,SRC). 2-(1-Methylpropyl)phenol's estimated vapor pressure, 0.05 mm Hg(3,SRC) and Henry's Law constant(1,SRC) indicate that volatilization from dry and moist soil will be slow(SRC).

Routes of exposure include dermal contact and vapor inhalation(1).

Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Symptoms: Irritation eyes, skin, respiratory system; skin burns Target Organs: Eyes, skin, respiratory system (NIOSH, 2016)|Corrosives

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. Phenols are very toxic poisons AND corrosive and irritating, so that inducing vomiting may make medical problems worse. IMMEDIATELY call a hospital or poison control center and locate activated charcoal, egg whites, or milk in case the medical advisor recommends administering one of them. If advice from a physician is not readily available and the victim is conscious and not convulsing, give the victim a glass of activated charcoal slurry in water or, if this is not available, a glass of milk, or beaten egg whites and IMMEDIATELY transport victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, assure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)|(See procedures)

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

ACUTE OCCUPATIONAL EXPOSURES HAVE RESULTED IN MILD RESP IRRITATION, AS WELL AS SKIN BURNS.

2-(1-methylpropyl)phenol

The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.|inhalation, skin absorption, ingestion, skin and/or eye contact

irritation eyes, skin, respiratory system; skin burns

Cough. Sore throat.

Pain. Blisters. Skin burns.

Redness. Pain. Blurred vision. Severe deep burns.

Eyes, skin, respiratory system

2-(1-Methylpropyl)phenol is obtained with high selectivity by reaction of phenol with n-butenes at 250-300 °C using gamma- aluminum trioxide as catalyst and at a pressure of 3.5-8.0 Mpa which keeps both reactants in the liquid phase.|Product purity is about 98%.

Phenol, 2-methyl(1-methylethyl)-: INACTIVE|Petrochemical manufacturing|Phenol, 2-(1-methylpropyl)-: ACTIVE

Health Hazards -> Corrosives