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Lanolin

pharmaceutical raw materials
Lanolin structure

Lanolin 

structure
  • CAS No:

    8006-54-0

  • Chemical Name:

    Lanolin

  • Synonyms:

    Lanolin;Agnolin No. 1;Alapurin;Anhydrous lanolin;Anhydrous Lanum;Lanain;Lanalin;Lanesin;Lanichol;Laniol;Oesipos;Agnolin;Adeps lane;Amber lanolin;Lanum;Processed lanolin;Cosmelan;Lantrol;Fats,lanolin;Fats,wool;Lanoprodine;Crodapur;Argowax;Clearlan 1650;Clearlan;HHC 82;FPG 1;Lanox HHC 82;Lanox HH 73;Lanox FPG 103;Lanox FPG 105;Lanox CNB 500;Lanox FP 1410N;Fats and Glyceridic oils,wool;Fats and Glyceridic oils,lanolin;Emery HP 2050;Lanox FP 85N;Lanox FP 8;Lanox FPK 108;Lanox CNB 50;Wool wax,lanolin;Coronet;Lanox CNB 80;Medilan;Super Lanolin;Natralube 210;Furuiran SP;Furuiran T;Fluilan T;E 913;Rikaranoru;Rikalanol;Medilan Ultra;Crodamol ODL;Lanolin TR;Corilene UL;TJ-F 402;YOFCO;Lanolins;Super Lanolin SO;Corona 8;Adeps Lanae;114471-15-7;8036-05-3;8038-41-3;8038-43-5;8040-96-8

  • Categories:

    Cosmetic Ingredient  >  Antistatic

Description

Lanolin, this precious gift of nature, derived from the delicate and tough fibers of wool, is a unique and versatile natural fat. Its color is as warm as the autumn afterglow, emitting a subtle natural aroma, not only gives the wool softness and luster, but also shows its value in many fields. Lanolin is unique in its excellent lubricity and moisturizing properties, thanks to its molecular structure containing both hydrophilic and hydrophobic groups, like nature's miniature ""water-locking guard"", which can be tightly attached to the skin, effectively locking in precious moisture, while building a solid protective barrier against the outside environment. Lanolin has long been an indispensable gem in the halls of medicine and beauty. For lactating women, the local pain and rupture of the nipple due to frequent breastfeeding is the unspeakable pain of many new mothers. The presence of Lanolin is undoubtedly a boon for these mothers. Its gentle and powerful repair ability can quickly penetrate deep into the damaged skin, relieve the discomfort caused by friction and dryness, and accelerate cell regeneration, promote the natural healing of the skin, so that the transmission of maternal love is no longer accompanied by pain. According to authoritative medical research, Lanolin has an effective rate of more than 90% in the treatment of lactation nipple pain and rupture, and its excellent curative effect has won wide recognition and praise. In addition, Lanolin's application in the field of skin care is equally broad and deep. On cold winter days, a moisturizer rich in Lanolin will quickly cover the skin with a warm protective coat, resist the invasion of cold winds, and keep the skin soft and elastic. For those who suffer from dry and chapped lips, a lip balm containing Lanolin is a lifesaver, providing long-lasting moisturization and protection with a single touch. What's more, Lanolin's mild, non-irritating properties make it ideal for baby skin care products that gently care for baby's delicate skin without dryness and rashes. With the advancement of science and technology and the improvement of people's health awareness, Lanolin's extraction and application technology is also constantly innovating and developing. Modern technology enables the purity and activity of Lanolin to be further enhanced to better play its unique skin care and health benefits. At the same time, more and more scientific research institutions and brands began to pay attention to Lanolin's environmental protection and sustainable development issues, committed to promoting the green transformation and upgrading of Lanolin industry.

Lanolin Basic Attributes

508.9

508.521931

232-348-6

15050000

Characteristics

26.3

log Kow = 15.60 (est)

White to yellow Adhering Crystals or Powder

0.932-0.945 g/cm3 @ Temp: 15 °C

38-42 °C

209 °C

soluble in ether, petroleum ether, chloroform and petroleum benzene. Sparingly soluble in ethanol. Insoluble in water.chloroform: 0.1 g/mL, clear to faintly turbid (<29 NTU), strongly yellow-green

Lanolin may gradually undergo autoxidation during storage. To inhibit this process, the inclusion of butylated hydroxytoluene is permitted as an antioxidant. Exposure to excessive or prolonged heating may cause anhydrous lanolin to darken in color and develop a strong rancidlike odor. However, lanolin may be sterilized by dry heat at 150°C. Ophthalmic ointments containing lanolin may be sterilized by filtration or by exposure to gamma irradiation.

Slight odor or practically odorless

Safety Information

NONH for all modes of transport

1

24/25

OE3201000

Lanolin Use and Manufacturing

Methods of Manufacturing

Preparation of crude lanolin using wool scouring sewage as raw material Add aluminum trichloride to wool scouring wastewater to obtain lanolin-containing sludge, which absorbs water to obtain sludge. Take 600kg of sludge, add 480kg of benzene, stir while adding, heat at 56℃ for 1h, stop stirring, precipitate for 1h, after clarification, the benzene solution will dissolve lanolin by 6%-40%, move it into the distillation tower, heat and distill until it contains lanolin. 34%, it is released when the temperature is lower than 40℃ to obtain crude lanolin. Scouring sewage [AlCl3]→sludge [benzene, 30℃]→Preparation of crude lanolin and phenyl grease Take 2100kg of crude lanolin and put it into the reaction pot, heat to 50℃, and then heat about 50% (g/g) The sulfuric acid solution was added to the crude lanolin, stirred for 45min, precipitated for half an hour, released the leg, added light ethanol to the phenyl fat layer, heated and kept at 60℃, stirred for half an hour, precipitated for half an hour, and released the leg to obtain acid-treated phenyl resin. Take acid-treated phenyl resin and add 180kg of ethanol, gradually add about 70kg of 300g/L sodium hydroxide solution, adjust pH9, add 180kg of water, keep the temperature at 60℃, and keep stirring from the time of ethanol addition to the completion of water addition, then continue to stir for 10 minutes, and let stand still , Precipitate for 1h, release the phenol, add light ethanol to the phenyl ester layer, stir, precipitate for 1h, release the lip to neutralize the phenyl ester. Crude lanolin [sulfuric acid, water]→[light ethanol] acid-treated phenyl ester [60℃, ethanol]→[NaOH, H2O] neutralized phenyl ester. Preparation of medicinal lanolin. Take neutralized phenyl ester and add 3.8% over 24kg of hydrogen oxide, stirring, keeping the temperature at 60°C, precipitating for 35 minutes, letting off the feet, maintaining pH 8-9, adding light ethanol, precipitating for 2 hours, letting off the feet, and obtaining refined phenyl resin. Distill, the liquid temperature is 110°C and vacuum evaporation until it can't be steamed, cool to 60°C, add ethanol, stir and precipitate for 1h, separate the lower layer of lanolin, add ethanol, heat and stir for 10min, discard the ethanol, and evaporate the ethanol under reduced pressure. Spun silk cloth is filtered to obtain medicinal lanolin. Neutralized phenyl fat [H2O2, ethanol, 60°C] → refined phenyl fat [ethanol, 110°C] → finished lanolin.

Uses

Emulsifier. Antifoaming agent. Rust inhibitor. Corrosion inhibitor. Pharmaceutical additives. Cosmetic preparation. Gas chromatographic fixative (maximum use temperature 200℃, solvent is chloroform), separation and analysis of non-polar compounds, ethanol, aromatic and heterocyclic compounds and volatile oil.

Drug Function and Efficacy

Lanolin is a wax secreted by the sebaceous glands of sheep, known for its excellent emollient and moisturizing properties. It can penetrate the skin quickly, soften and rehydrate cracked or dry skin, and enhance the skin's barrier function. It also has mild anti-inflammatory and antimicrobial effects, supporting wound healing and skin repair.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Registered Holders

  • Shanghai Zhouhui Lanolin Co., Ltd.

    China China
    Active
  • Hunan Haiji Pharmaceutical Co., Ltd.

    China China
    Active
  • Nippon Fine Chemical Co., Ltd.

    European Union European Union
    Active

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