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Cefpodoxime

Cefpodoxime structure

CAS No:
80210-62-4
Formula:
C15H17N5O6S2
Chemical Name:
Cefpodoxime
Synonyms:
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-,(6R,7R)-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-,[6R-[6α,7β(Z)]]-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-,(6R,7R)-;(6R,7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;R 3763;Cefpodoxime;Cefpodoxime acid
Categories:
Active Pharmaceutical Ingredients > Antibiotics

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Description

Off-White Solid

Cefpodoxime Basic Attributes

Molecular Weight：

427.46

Exact Mass：

427.46

DSSTox ID：

DTXSID6022765

ATC Code：

J - Antiinfectives for systemic use

Characteristics

PSA：

209.98000

XLogP3：

0.94

Density：

1.8±0.1 g/cm3

Melting Point：

200-202°C

Refractive Index：

1.780

Water Solubility：

soluble in DMSO

Storage Conditions：

-20°C Freezer

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

42/43

safety instructions：

22-36/37-45

RTECS Number：

XI0367365

Marks：

Precautionary statement(s)：

P261-P280-P342 + P311

Hazard Statements：

H317-H334

GHS Classification：

|Danger|H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]|P261, P272, P280, P285, P302+P352, P304+P341, P321, P333+P313, P342+P311, P363, and P501|Aggregated GHS information provided by 39 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

MeSH Entry Terms：

cefpodoxime

Cefpodoxime Use and Manufacturing

Cefpodoxime Proxetil metabolite antibiotic

Computed Properties

Molecular Weight:427.5
XLogP3:-1.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:7
Exact Mass:427.06202563
Monoisotopic Mass:427.06202563
Topological Polar Surface Area:210
Heavy Atom Count:28
Complexity:744
Undefined Atom Stereocenter Count:2
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Cefpodoxime proxetil is an oral broad-spectrum third-generation cephalosporin. After entering the body, it is hydrolyzed into cefpodoxime by nonspecific esterase to exert antibacterial effects. It is effective against both Gram-positive and Gram-negative bacteria. It achieves bactericidal effects by inhibiting the biosynthesis of microbial cell walls. It is stable to β-lactamase and is still sensitive to many β-lactamase-producing microorganisms that are resistant to penicillin and cephalosporins. It is ineffective against some ultra-extended-spectrum β-lactamases.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Cefpodoxime Proxetil Granules
Ingredients	The main ingredient of this product is cefpodoxime, and its chemical name is: (6R, 7R)-7-[2-(2-aminothiazol-4-yl)-(Z)-2-(methoxyimino)acetylamino]-3-methoxymethyl-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid-1-(isopropoxycarbonyloxy)ethyl ester.
Indication	Antacids or H2 receptor antagonists can reduce its absorption and lower its peak plasma concentration; probenecid can increase its plasma concentration level.
Specifications	40mg (calculated as C15H17N5O6S2)
Manufacturer	Tianjin Pharmaceutical HOLDINGS Gencom Pharmacy Co., Ltd.

Cefpodoxime Proxetil Granules
Ingredients	The main ingredient of this product is cefpodoxime, and its chemical name is: (6R, 7R)-7-[2-(2-aminothiazol-4-yl)-(Z)-2-(methoxyimino)acetylamino]-3-methoxymethyl-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid-1-(isopropoxycarbonyloxy)ethyl ester.
Indication	Antacids or H2 receptor antagonists can reduce its absorption and lower its peak plasma concentration; probenecid can increase its plasma concentration level.
Specifications	40mg (calculated as C15H17N5O6S2)
Manufacturer	Tianjin Pharmaceutical HOLDINGS Gencom Pharmacy Co., Ltd.

Registered Holders

Sun Pharmaceutical Industries Ltd

United States
Inactive

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Baoji Guokang Bio-Technology Co.,Ltd Contact Supplier

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Cefpodoxime Medical Grade

CAS No.: 80210-62-4

Grade: Medical Grade

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Shanghai Kangxin Chemical Co., Contact Supplier

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Cefpodoxime Acid pharm ingredients high purity best price

CAS No.: 80210-62-4

Grade: medical grade

Content: 98%

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