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Modecainide

Modecainide structure

CAS No:
81329-71-7
Formula:
C22H28N2O3
Chemical Name:
Modecainide
Synonyms:
Benzamide,4-hydroxy-3-methoxy-N-[2-[2-(1-methyl-2-piperidinyl)ethyl]phenyl]-;Benzamide,4-hydroxy-3-methoxy-N-[2-[2-(1-methyl-2-piperidinyl)ethyl]phenyl]-,(±)-;4-Hydroxy-3-methoxy-N-[2-[2-(1-methyl-2-piperidinyl)ethyl]phenyl]benzamide;MJ 14030;3-Methoxy-O-demethyl encainide;Modecainide;3-Methoxy-O-desmethylencainide;BMY 40327;(±)-2′-(2-(1-Methyl-2-piperidyl)ethyl)vanillanilide;82522-70-1
Categories:
Organic Chemistry > Amides

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Description

Modecainide is a major metabolite of Encainide, which is an antiarrhythmic agent.

Modecainide Basic Attributes

Molecular Weight：

368.477

Exact Mass：

368.47

Characteristics

PSA：

61.8

XLogP3：

4.39190

Density：

1.162g/cm3

Boiling Point：

480.6ºC at 760 mmHg

Flash Point：

244.4ºC

Refractive Index：

1.598

Drug Information

MeSH：

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

MeSH Entry Terms：

3-methoxy-4-hydroxyencainide

Modecainide Use and Manufacturing

Cardiac depressant (anti-arrhythmic).

Computed Properties

Molecular Weight:368.5
XLogP3:3.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:368.20999276
Monoisotopic Mass:368.20999276
Topological Polar Surface Area:61.8
Heavy Atom Count:27
Complexity:473
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes