5-Chloro-2-methoxyaniline

Off-white to tan crystalline powder or flakes

Take 4-chloro-o-nitroanisole as raw material, reduce with iron powder to obtain crude product, and then use hydrochloric acid to make hydrochloride to obtain finished product. . Add 1500kg of water and 15kg of formic acid to the reduction pot, then add 4000kg of 4-chloro-o-nitroanisole, stir and heat the mixture to boiling, add 4000kg of iron filings, the addition rate of iron filings depends on the reaction speed, about 10- 12h. When iron filings are added to 2000kg (or the reaction rate tends to be slow), 15kg of formic acid is added. After the reaction, 800L of naphtha was added for extraction, and the naphtha layer was separated by standing. The iron oxide was extracted with naphtha twice, 800L each time. Merge the naphtha layer. The naphtha was evaporated with superheated steam, and the 4-chloroanthranil-water layer was vacuum distillation to obtain crude 4-chloroanthranil, with a melting point of about 79°C. Because the product is unstable, vacuum distillation is carried out several times (only a small amount is evaporated each time). Add 2000L 8% dilute hydrochloric acid to the salt-forming pot, stir and heat to 70℃, add 600kg 4-chloroanthranil, stir at 70℃ for 2h, then add 450kg 40% hydrochloric acid, and cool to 15-20℃, the product Separation, vacuum filtration, dehydration, drying at 70-75°C, and grinding to obtain finished products. The mother liquor can be reused 7-8 times.

Dye intermediate.

Molecular Weight:157.60
XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:157.0294416
Monoisotopic Mass:157.0294416
Topological Polar Surface Area:35.2
Heavy Atom Count:10
Complexity:110
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes