2,5-Dichloroaniline

162.02

162.02

1447438

202-455-2

7U61VY7POL

0142

1492

3442|1590

DTXSID6024967

Light brown or amber-colored crystalline mass|NEEDLES FROM PETROLEUM ETHER

29214210

26

2.75

2,5-dichloroaniline is a brown crystalline solid. (NTP, 1992)

1.54 g/cm³

50 °C

251 °C

>230 °F

1.614

H2O: ca. 0.56 g/L (20 ºC);soluble in dilute hydrochloric acid.

Store below +30°C.

Vapour pressure, Pa at 25°C:

Relative vapour density (air = 1): 5.6

Oral-rat LD50: 1600 mg/kg;Oral-Mouse LD50: 1600 mg/kg

Open flame is flammable; heat decomposes toxic chloride and nitrogen oxide fumes

Explodes spontaneously.

This chemical is sensitive to prolonged exposure to heat, light and air. (NTP, 1992). Insoluble in water.

Aryl Halides

2,5-DICHLOROANILINE is incompatible with acids, acid chlorides, acid anhydrides and oxidizing agents. (NTP, 1992)

540 °C

II

6.1

UN 3442 6.1/PG 2

3

23/24/25-33-50/53

28-36/37-45-60-61-28A

BX2610000

T,N

The warehouse is ventilated, low temperature and dry; stored separately from oxidants, food additives and acids

Toxic

Stable. Incompatible with acids, acid chlorides, acid anhydrides, oxidizing agents.

P261-P273-P280-P301 + P310-P311-P501

H301 + H311 + H331-H373-H410

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

This chemical is combustible. (NTP, 1992)|Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Heating will cause rise in pressure with risk of bursting.

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P260, P261, P264, P270, P271, P273, P280, P301+P310, P302+P352, P304+P340, P311, P312, P314, P321, P322, P330, P361, P363, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 210 companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H301: Toxic if swallowed [Danger Acute toxicity, oral]|P260, P261, P264, P270, P271, P272, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P310, P311, P312, P314, P321, P322, P330, P333+P313, P361, P363, P403+P233, P405, and P501|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P260, P261, P264, P270, P272, P280, P301+P312, P302+P352, P305+P351+P338, P309+P311, P310, P314, P321, P330, P333+P313, P363, P405, and P501

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, you should dampen the solid spill material with alcohol, then transfer the dampened material to a suitable container. Use absorbent paper dampened with alcohol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with alcohol followed by washing with a strong soap and water solution. Do not reenter the contaminate area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should keep this material in a tightly-closed container under an inert atmosphere, and store it in a freezer or refrigerator. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)|POSSIBLE EXPOSURE TO HIGHER CONCN (PIPE BREAKAGE, SPLASHING, CLEANING OR REPAIR OF STORAGE TANKS) NECESSITATES USE OF SAFETY GOGGLES, GAS MASK, APRON, & RUBBER GLOVES. /ANILINE/|RESPIRATOR FOR ORGANIC VAPORS, SPLASHPROOF GOGGLES ... /&/ BOOTS. /ANILINE/|Respiratory protection from aniline is as follows: vapor concentration of 100 ppm or less: a chemical cartridge respirator with a full facepiece and an organic vapor cartridge(s) or a gas mask with a chin-style front or back-mounted organic vapor canister or any supplied-air respirator with a full facepiece, helmet or hood, or any self-contained breathing apparatus with a full facepiece; greater than 100 ppm or entry and escape from unknown concentrations: self-contained breathing apparatus with a full facepiece operated in pressure demand or other positive pressure mode or a combination respirator which includes a type C supplied-air respirator with a full facepiece operated in pressure-demand or other positive pressure or continuous-flow mode and an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive pressure mode; escape: any gas mask providing protection against organic vapors or any self-contained breathing apparatus. /Aniline/|Butyl rubber protective clothing. ... /Aniline/|Wear special protective clothing and positive pressure self-contained breathing apparatus. /Dichloroanilines/

Explodes spontaneously.

If material on fire or involved in fire: Use dry chemical or carbon dioxide. Cool all affected containers with flooding quantities of water. use water in flooding quantities as fog. /Dichloroaniline/|Personnel protection: ... Wear positive pressure self-contained breathing apparatus when fighting fires involving this material. /Dichloroaniline/

... ANILINE SHOULD BE REACTED IN CLOSED VESSELS AS FAR AS POSSIBLE. IN FACTORIES VENTILATION SHOULD BE SUFFICIENT TO KEEP ATMOSPHERIC ANILINE CONTENT WELL BELOW PERMITTED LEVEL. /ANILINE/|Eating and smoking should not be allowed in areas where liquid aniline is handled, processed, or stored. /Aniline/|Clothing which becomes soaked with aniline should be promptly removed. /Aniline/|In the case of /skin/ contact it should be washed for a long time with soap & tepid water. When eyes are /exposed to aniline/ copious irrigation with water is immediately necessary. ... /Aniline/|For more Preventive Measures (Complete) data for 2,5-DICHLOROANILINE (8 total), please visit the HSDB record page.

/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Health: TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. /Dichloroanilines; Dichloroanilines, liquid; Dichloroanilines, solid/|/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Fire or Explosion: Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. /Dichloroanilines; Dichloroanilines, liquid; Dichloroanilines, solid/|/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas. /Dichloroanilines; Dichloroanilines, liquid; Dichloroanilines, solid/|/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Dichloroanilines; Dichloroanilines, liquid; Dichloroanilines, solid/|For more DOT Emergency Guidelines (Complete) data for 2,5-DICHLOROANILINE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Personal protection: chemical protection suit including self-contained breathing apparatus. Remove all ignition sources. Do NOT wash away into sewer. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. Carefully collect remainder. Then store and dispose of according to local regulations.

Separated from strong oxidants and food and feedstuffs.

No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.

The substance is severely irritating to the eyes. The substance may cause effects on the blood. This may result in the formation of methaemoglobin. Exposure could cause death. The effects may be delayed. Medical observation is indicated.

Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the blood. This may result in the formation of methaemoglobin.

NO open flames.

PREVENT DISPERSION OF DUST!

Use local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear safety goggles or face shield.

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. 2,5-Dichloroaniline is produced, as an intermediate or a final product, by process units covered under this subpart.

No reaction product was found when 2,5-dichloroaniline was heated over K-10 and the other ion-exchanged montmorillonites (Fe+3, Cu+2, Al+3) over a six hour period in n-hexane(1).

moderately toxic

LD50 Rat oral 1600 mg/kg|LD50 Rat ip 400 mg/kg|LD50 Mouse oral 1600 mg/kg|LD50 Mouse ip 400 mg/kg|LD50 Mouse iv 56 mg/kg

2,5-Dichloroaniline's production and use as a dye intermediate(1) may result in its release to the environment through various waste streams(SRC). Aromatic amines such as 2,5-dichloroaniline are introduced into the environment directly as industrial effluents and indirectly as transformation products from pesticides or pharmaceuticals(2). 2,5-Dichloroaniline has been identified as a degradation product of Acid Dye 13155(3).

TERRESTRIAL FATE: Based on a classification scheme(1), a Koc value of 355(2) indicates that 2,5-dichloroaniline is expected to have moderate mobility in soil(SRC). However, when released to soil containing humic material, 2,5-dichloroaniline may undergo a covalent chemical bonding resulting in its chemical alteration to a latent form resulting in strong adsorption(3). 2,5-Dichloroaniline demonstrated almost a linear rate of decomposition in Guelph loam over a 12 week period, with a half-life of 8 weeks(4). Volatilization of 2,5-dichloroaniline from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.6X10-6 atm-cu m/mole(SRC), using a fragment constant estimation method(5). 2,5-Dichloroaniline is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 1.5X10-2 mm Hg(SRC), determined from a fragment constant method(6).|AQUATIC FATE: Based on a classification scheme(1), a Koc value of 355(2) indicates that 2,5-dichloroaniline is expected to adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 1.6X10-6 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Volatilization half-lives for a model river and model lake are 30 and 219 days, respectively(SRC), using an estimation method(3). However, this model underestimates the volatilization half-life of 2,5-dichloroaniline since it does not take into account the effects of adsorption. The Koc of 355(2) suggests that volatilization could be attenuated by adsorption to suspended solids and sediments in water(SRC). This is apparent from the results of two EXAMS model runs, one in which the effect of adsorption was considered, yielding an estimated half-life of 662 days in a model pond 2 m deep, and one in which the effect of adsorption was ignored, yielding an estimated half-life of 317 days in a model pond 2 m deep(5). According to a classification scheme(6), an estimated BCF of 35(3,SRC), from a log Kow value of 2.92(2), suggests the potential for bioconcentration in aquatic organisms is moderate.|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semi-volatile organic compounds in the atmosphere(1), 2,5-dichloroaniline, which has an estimated vapor pressure of 1.5X10-2 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 2,5-dichloroaniline is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 17 hours(SRC) from its estimated rate constant of 2.2X10-12(3).

The rate constant for the vapor-phase reaction of 2,5-dichloroaniline with photochemically-produced hydroxyl radicals has been estimated as 2.2X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 17 hours at an atmospheric concn of 5X10+5 hydroxyl radicals per cu cm(1). 2,5-dichloroaniline is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(3) nor to directly photolyze due to the lack of absorption in the environmental UV spectrum.

15.14|An estimated BCF of 35 was calculated for 2,5-dichloroaniline(SRC), using log Kow of 2.92(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate.

The Koc for 2,5-dichloroaniline is 355(1). According to a classification scheme(2), this Koc value suggests that 2,5-dichloroaniline is expected to have moderate mobility in soil. However, when released to soil containing humic material, 2,5-dichloroaniline may undergo a covalent chemical bonding resulting in its chemical alteration to a latent form resulting in strong adsorption(3).

The Henry's Law constant for 2,5-Dichloroaniline is estimated as 1.6X10-6 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that 2,5-dichloroaniline is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as approximately 30 days(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as approximately 219 days(SRC). However, the volatilization half-life does not take into account the effects of adsorption. A Koc of 355(3) suggests that volatilization could be attenuated by adsorption to suspended solids and sediments in water(SRC). This is apparent from the results of two EXAMS model runs, one in which the effect of adsorption was considered, yielding an estimated half-life of 662 days in a model pond 2 m deep, and one in which the effect of adsorption was ignored, yielding an estimated half-life of 317 days in a model pond 2 m deep(4). 2,5-Dichloroaniline's Henry's Law constant(1) indicates that volatilization from moist soil surfaces may occur(SRC). 2,5-Dichloroaniline is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 1.5X10-2 mm Hg(SRC), determined from a fragment constant method(5).

GROUNDWATER: 2,5-Dichloroaniline was detected in 8 out of 8 wells sampled from an industrialized area in Milan, Italy between Nov 1995 to Nov 1996, concns not specified(1).|SURFACE WATER: Water samples of the Elbe River near Hamburg Germany were analyzed for 2,5-dichloroaniline in 1992. Samples taken upstream of Hamburg at Zollenspieker had concns of 13 ng/l (minimum) 65 ng/l (max) and 31 ng/l (median) while samples downstream at Seem had concns of 6.6 ng/l (minimum) 70 ng/l (max) and 24 ng/l (median) of 2,5-dichloroaniline(1). Samples of 100 l were taken from the North Sea at a depth of 5 m. 2,5-Dichloroaniline was detected at 0.038, 0.036, 0.20, 0.064, 0.46, and 0.19 ng/l at points 1, 4, 9, 27, 30, and 36 respectively in the North Sea in 1990. In 1995, 2,5-dichloroaniline was detected only at points 27, 30, and 36 at concns of 0.65, 0.30, and 0.060 ng/l, respectively (limits of detection 0.01 ng/l)(2). In 1979, 2,5-Dichloroaniline was detected along the Rhine River in 13 of 46 samples at Lobith, Germany (0.39 ppb (max) and 0.04 ppb (mean)), 4 of 12 samples at Boven Merwede, Netherlands (0.32 ppb (max) and 0.05 ppb (mean)) and 3 of 13 samples at Ijssel, Netherlands (0.40 ppb (max) and 0.04 ppb (mean)). 2,5-Dichloroaniline was detected along the Meuse River in 0 of 9 samples at Eijsden, Netherlands and 2 of 12 samples at Lith, Netherlands (0.07 ppb (max) and 0.01 ppb (mean))(3).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 2,819 workers (246 of these are female) are potentially exposed to 2,5-dichloroaniline in the US(1). Occupational exposure to 2,5-dichloroaniline may occur through inhalation and dermal contact with this compound at workplaces where 2,5-dichloroaniline is produced or used(SRC). The general population may be exposed to 2,5-dichloroaniline via drinking water(2-4) and dermal contact with this compound in dye products(5) containing 2,5-dichloroaniline.

The metabolic fate of propanil in plants was studied. The conversion of this compound in soil to 3,3',4,4'-tetrachloroazobenzene is catalyzed by soil peroxidases. This reaction also occurs in the presence of crystalline horseradish peroxidase. In some plants propanil is rapidly hydrolyzed to give 3,4-dichloroaniline. Crude extracts of barnyard grass, fresh horseradish root, rice & commercially purified crystalline horseradish enzyme were prepared. It was inferred that the differences in substrate specificity among peroxidases may account for the failure of some plants to convert the aniline to azo compounds such as in the conversion to 3,4-dichloroaniline to 3,3',4,4'-tetrachloroazobenzene. ... Enzymatically catalyzed products of mono- & dichloroanilines were prepared by mixing barnyard grass supernatants or horseradish peroxidase with an acetic buffer, hydrogen peroxide & various aniline substrates & allowed to react for 30 min. Preparations made from fresh horseradish & from horseradish peroxidase gave products with all anilines except 2,5- & 2,6-dichloroanilines. Barnyard grass & rice plants gave products only with 2,3-dichloroaniline of the dichloroaniline substrates studied. /Dichloroanilines/

0.07 Days

SYMPTOMS: Symptoms of exposure to this compound may include irritation of the skin, eyes, and mucous membranes. ACUTE/CHRONIC HAZARDS: This compound is a local irritant. It emits toxic fumes when heated to decomposition. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Basic treatment: Establish patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Aniline and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W TKO /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation. /Aniline and related compounds/

The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Blue lips, fingernails and skin. Dizziness. Headache. Nausea. Shortness of breath. Confusion. Convulsions. Unconsciousness.

MAY BE ABSORBED! Further see Inhalation.

Redness. Pain. Blurred vision.

Benzenamine, 2,5-dichloro-: ACTIVE

APPLICATION OF THE HALL ELECTROLYTIC CONDUCTIVITY DETECTOR FOR THE ANALYSIS OF CHLOROANILINES & CHLORONITROANILINES IN POTW (WATER TREATMENT) SLUDGES. /CHLOROANILINES AND CHLORONITROANILINES/|APPLICATIONS OF FUSED SILICA CAPILLARY COLUMNS TO THE ANALYSIS OF ENVIRONMENTAL SAMPLES WERE PRESENTED. THE CHROMATOGRAPHIC BEHAVIOR (RETENTION TIME, RELATIVE RETENTION TIME) OF ORGANIC COMPOUNDS OF ENVIRONMENTAL SIGNIFICANCE NOT LISTED AS CONSENT DECREE PRIORITY POLLUTANTS WAS INVESTIGATED ON AN SE-54 FSCC. RETENTION INDICES & MASS SPECTRAL RESPONSE FACTORS WERE PRESENTED FOR 28 COMPOUNDS INCLUDING A NUMBER OF CHLORO- & NITRO-SUBSTITUTED ANILINES, ALKYLPYRIDINES AND ALKYLQUINOLINE DERIVATIVES. THE DIRECT APPLICATION OF THE FUSED SILICA CAPILLARY COLUMN/MASS ANALYSIS OF THESE COMPOUNDS IN ACTUAL ENVIRONMENTAL SAMPLES WAS PRESENTED, INCLUDING VENT EMISSIONS FROM A FUNGICIDE MANUFACTURING PROCESS & CONTAMINATED SOIL & WATER SAMPLES FROM TWO METROPOLITAN BOSTON (MASSACHUSETTS USA) CONSTRUCTION SITES. /CHLORO- AND NITRO-SUBSTITUTED ANILINES/

It is possible to separate urea compounds from chloroaniline, occurring often as metabolites of the former, by high-pressure liquid chromatography. Silica gel is used as stationary phase & depending on the kind of groups to be separated, various hexane: methylene chloride mixtures are used as mobile phase. This isocratic elution is usually unfeasable in the case of urea herbicides associated with chloroanilines of greatly varying polarity. In this case, the polarity of the mobile phase must be adjusted to that of the substances to be eluted. /Chloroanilines/