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Etilefrine hydrochloride

Etilefrine hydrochloride structure

CAS No:
943-17-9
Formula:
C10H15NO2.ClH
Chemical Name:
Etilefrine hydrochloride
Synonyms:
Benzenemethanol,α-[(ethylamino)methyl]-3-hydroxy-,hydrochloride (1:1);Benzyl alcohol,α-[(ethylamino)methyl]-m-hydroxy-,hydrochloride;Benzenemethanol,α-[(ethylamino)methyl]-3-hydroxy-,hydrochloride;α-[(Ethylamino)methyl]-m-hydroxybenzyl alcohol hydrochloride;1-(3-Hydroxyphenyl)-2-ethylaminoethanol hydrochloride;Etilefrine hydrochloride;Funasol;dl-Effortil hydrochloride;(±)-N-Ethylnorphenylephrine hydrochloride;dl-N-Ethylnorphenylephrine hydrochloride;dl-1-(3-Hydroxyphenyl)-1-hydroxy-2-ethylaminoethane hydrochloride;dl-1-(3-Hydroxyphenyl)-2-ethylaminoethanol hydrochloride;dl-Ethylphenylephrine hydrochloride;(±)-Ethylphenylephrine hydrochloride;Ethyl adrianol;Effontil;Effortil;Updormin;Phetanol;Ethylephrine hydrochloride;Tonus-Forte;Apocretin;Eti-Puren;Kertasin;dl-Etilefrin hydrochloride;Circupon;Effortilvet;Pulsamin;534-87-2
Categories:
Analytical Chemistry > Standard

Description

White or almost white, crystalline powder or colourless crystals.

Etilefrine hydrochloride (TN) is a member of phenols.|A phenylephrine-related beta-1 adrenergic and alpha adrenergic agonist used as a cardiotonic and antihypotensive agent.

Etilefrine hydrochloride Basic Attributes

Molecular Weight：

217.69

Exact Mass：

217.086960

EC Number：

213-398-8

DSSTox ID：

DTXSID1045322

HScode：

2922509090

Characteristics

PSA：

52.5

XLogP3：

2.22800

Appearance：

white

Density：

1.127g/cm3

Melting Point：

121 °C

Boiling Point：

351.7ºC at 760 mmHg

Flash Point：

155.5ºC

Water Solubility：

Freely soluble in water, soluble in ethanol (96 per cent), practically insoluble in methylene chloride

Safety Information

Transport codes：

UN 2811 6.1 / PGIII

RTECS Number：

DO5618000

Precautionary statement(s)：

Missing Phrase - N15.00950417-P305 + P351 + P338

Hazard Statements：

H301-H319

GHS Classification：

|Danger|H301 (97.62%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P280, P301+P310, P305+P351+P338, P321, P330, P337+P313, P405, and P501|Aggregated GHS information provided by 42 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH：

Drugs that selectively bind to and activate alpha adrenergic receptors. (See all compounds classified as Adrenergic alpha-Agonists.)|Compounds that bind to and activate ADRENERGIC BETA-1 RECEPTORS. (See all compounds classified as Adrenergic beta-1 Receptor Agonists.)|Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE). (See all compounds classified as Cardiotonic Agents.)|Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)|Drugs used to cause constriction of the blood vessels. (See all compounds classified as Vasoconstrictor Agents.)

MeSH Entry Terms：

Adrenam

Etilefrine hydrochloride Use and Manufacturing

Adrenoceptor agonist.

Computed Properties

Molecular Weight:217.69
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:217.0869564
Monoisotopic Mass:217.0869564
Topological Polar Surface Area:52.5
Heavy Atom Count:14
Complexity:141
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes