Oxybuprocaine

308.42

308.42

AXQ0JYM303

DTXSID7048530

S01HA02|D - Dermatologicals|S - Sensory organs

2922509090

64.8

3.1

Solid

1.052g/cm3

216.5 °C

216.5 °C

224.1ºC

1.524

Very soluble (hydrochloride salt)

Used to temporarily numb the front surface of the eye so that the eye pressure can be measured or a foreign body removed.

Oxybuprocaine is a local anaesthetic. It may be less irritating than tetracaine, and the onset and duration of action are similar to tetracaine.

Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate. (See all compounds classified as Anesthetics, Local.)

Oxybuprocaine binds to sodium channel and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. Depolarization of the neuronal membrane is inhibited thereby blocking the initiation and conduction of nerve impulses.

benoxinate

Pharmaceuticals