Oxybuprocaine hydrochloride
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Oxybuprocaine hydrochloride
structure -
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CAS No:
5987-82-6
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Formula:
C17H28N2O3.ClH
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Chemical Name:
Oxybuprocaine hydrochloride
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Synonyms:
Benzoic acid,4-amino-3-butoxy-,2-(diethylamino)ethyl ester,hydrochloride (1:1);Benzoic acid,4-amino-3-butoxy-,2-(diethylamino)ethyl ester,monohydrochloride;2-(Diethylamino)ethyl 4-amino-3-butoxybenzoate hydrochloride;Dorsacaine hydrochloride;Benoxinate hydrochloride;Novesine;Novesin;Dorsacaine;Oxybuprocaine hydrochloride;Conjucaine;Boxinate;Benoxil;Cebesine;Conjuncain;Lacrimin;Minims
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CAS No:
Description
White or almost white, crystalline powder or colourless crystals.
Oxybuprocaine hydrochloride is the monohydrochloride salt of oxybuprocaine. It has a role as a local anaesthetic. It contains an oxybuprocaine.
Characteristics
64.8
4.32950
155 °C
446.9ºC at 760 mmHg
224.1ºC
LD50 scu-rat: 60 mg/kg NIIRDN 6,154,82
Safety Information
UN 1544PSN2 6.1 / PGIII
3
36/37/38-20/21/22
22-26-36
DG1502900
Xi,Xn
P305 + P351 + P338
H315-H319-H335
Drug Information
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate. (See all compounds classified as Anesthetics, Local.)
benoxinate
Oxybuprocaine hydrochloride Use and Manufacturing
The ethyl ester obtained by esterifying 3-oxo-4-nitrobenzoic acid with ethanol is reacted with butyl bromide to obtain ethyl butoxynitrobenzoate, which is saponified with caustic alkali to produce 3-butoxy-4 -Nitrobenzoic acid. Then, it is reacted with thionyl chloride to obtain an acid chloride intermediate, which is then esterified with diethylaminoethanol to obtain diethylaminoethyl 3-butoxy-4-nitrobenzoate, which is prepared by reduction to a salt Butoxyprocaine hydrochloride.
anticonvulsant
Computed Properties
Molecular Weight:344.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:11
Exact Mass:344.1866705
Monoisotopic Mass:344.1866705
Topological Polar Surface Area:66
Heavy Atom Count:23
Complexity:308
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
No specific pharmacological effects mentioned
Registered Holders
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SIEGFRIED EVIONNAZ SA
Active
France
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Shandong Haiyou Freda Pharmaceutical Co., Ltd.
Active
China
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Shandong Chenlong Pharmaceutical Co., Ltd.
Active
China
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