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Corticotropin

Corticotropin structure

CAS No:
9002-60-2
Chemical Name:
Corticotropin
Synonyms:
Corticotropin;Acethropan;Acorto;ACTH;Acton;Actonar;Adrenal cortex hormone;Adrenocorticotrophic hormone;Adrenocorticotrophin;Adrenomone;Cibacthen;Corstiline;Cortiphyson;Cortrophin;Reacthin;Solacthyl;Adrenocorticotropic hormone;Adrenocorticotropin;Corticotropin-like substances;Dynamone;Exacthin;Adrenotrophin;Corticotrophin;Duracton;ProActon;Humactid;Nuvacthen;Chorionic corticotropin;Acthormone;Adrenocorticotropin hormone;Acton (hormone);Cortrophimn;Tubex;Acortan;Alfatrofin;Isactid;8049-43-2;8049-37-4;8049-87-4;8049-68-1;8049-86-3;9006-61-5;9040-10-2;55127-96-3
Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System

Description

ChEBI: A polypeptide hormone produced and secreted by the pituitary gland comprising 39 amino acid residues coupled in a linear sequence. The N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic act vity. Corticotropin stimulates the cortex of the adrenal gland and boosts the synthesis of corticosteroids, mainly glucocorticoids but also sex steroids (androgens). It is used in the treatment of certain neurological disorders such as infantile spasms

Corticotropin Basic Attributes

Molecular Weight：

4541.1

Exact Mass：

4538.26000

EC Number：

232-659-7

HScode：

2937190000

Characteristics

PSA：

1861.55000

XLogP3：

5.65470

Appearance：

powder

Water Solubility：

H2O: 1 mg/mL, clear, colorless

Storage Conditions：

−20°C

Flammability characteristics：

Combustible

Safety Information

wgk germany：

hazard class code：

20/21/22-40

safety instructions：

22-36

RTECS Number：

GM7900000

Marks：

Storage features：

Treasury is ventilated, low temperature and dry; stored separately from food materials

Stability/Shelf Life：

Solutions are stable to heat. an aqueous solution buffered to pH 7.5 may be put in a boiling water bath for at least 120 min. In 0.10 molar HCl an 0.2% solution retains its biological potency when kept at 100 °C for 60 min, but in 0.10 molar NaOH the activity is lost within 30 min. At 60 °C at 0.2% solution at pH 10.8 maintains its potency for 60 min. In general the substance is more stable in acid solution.

Corticotropin Use and Manufacturing

Hormonal drugs, which promote the secretion of adrenal cortex hormones, are used for collagen diseases such as active rheumatism, rheumatoid arthritis, and lupus erythematosus. Clinical use is similar to cortisone.

Computed Properties

Molecular Weight:4541
XLogP3:-19.7
Hydrogen Bond Donor Count:63
Hydrogen Bond Acceptor Count:68
Rotatable Bond Count:148
Exact Mass:4540.2660828
Monoisotopic Mass:4538.2593732
Topological Polar Surface Area:1860
Heavy Atom Count:322
Complexity:11200
Defined Atom Stereocenter Count:36
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Sodium carboxymethyl cellulose

Drug Function and Efficacy

It can stimulate the adrenal cortex, causing it to proliferate and increase in weight, and increase the synthesis and secretion of adrenal cortical hormones, mainly glucocorticoids (cortisol). Mineralocorticoids (aldosterone) increase in the early stages of medication, but will no longer increase with continued medication. The synthesis and secretion of adrenal androgens also increase.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Corticotropin for injection
Ingredients	Ingredients: Corticotropin, a sterile freeze-dried product with appropriate excipients.
Indication	When used in combination with alkaline solutions during intravenous drip, turbidity and ineffectiveness may occur; use with potassium-excreting diuretics will aggravate potassium loss; when used for a long time, combined with salicylic acid drugs, indomethacin, etc., gastrointestinal ulcers may occur or aggravate; when used by diabetics, the dosage of hypoglycemic drugs must be adjusted or increased due to the hyperglycemic effect of this drug; the effect of oral anticoagulants may be reduced.
Specifications	25 units
Manufacturer	SPH NO.1 Biochemical & Pharmaceutical Co., Ltd.

ACTH

THINNR BOOST- adeps suillus, andrenalinum, adrenocorticotrophin, calcarea carbonica, chelidonium, pituitarum, thyroidinum_liquid
Manufacturer	SLIMCELL, LLC

See More Related Drugs

Registered Holders

SPH NO.1 Biochemical & Pharmaceutical Co., Ltd.

China
Active
Ferring Holding AB

Sweden
Inactive
UNITED STATES PHARMACOPEIA

United States
Inactive

See More Registered Holders

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