Trisodium citrate

258.06900

257.97300

200-675-3

RS7A450LGA

1218

DTXSID2026363|DTXSID1027348

B - Blood and blood forming organs

2918150000

140.62000

-5.25260

DryPowder; Liquid; OtherSolid; PelletsLargeCrystals

1.008 g/mL at 20°C

300°C

BP: Decomposes at red heat /Dihydrate/

H2O: 29.4g/L

2-8°C

LD50 in rats, mice (mmol/kg): 6.0, 5.5 i.p. (Gruber, Halbeisen)

Between 7,5 and 9,0 (5 % aqueous solution)

Relatively large, colorless crystals or white granules /Pentahydrate/

NONH for all modes of transport

2

R22; R40; R48/20/22

S36; S24/25

GE8300000

Xi,C

NOT AS STABLE AS DIHYDRATE; DRYING OUT ON EXPOSURE TO AIR & ALSO CAKING /PENTAHYDRATE/

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

H315

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended; 21 U.S.C. 321-392).|Trisodium citrate is a prior sanctioned food ingredient classified as a stabilizer when migrating from food-packaging material.

Combustible.

Not Classified

Use water spray, powder.

Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water.

Evaporation at 20 °C is negligible; a nuisance-causing concentration of airborne particles can, however, be reached quickly when dispersed.

The substance is irritating to the eyes and respiratory tract.

NO open flames.

Use ventilation (not if powder).

Wear safety spectacles.

Overdose toxicity is mainly due to alkalosis as well as tetany or depressed heart function due to lack of free calcium.

Used as an anticoagulant during plasmophoresis as well as a neutralizing agent in the treatment of upset stomach and acidic urine.|FDA Label

...USED AS AN EXPECTORANT...& SYSTEMIC ALKALIZER. SALINE EXPECTORANTS ARE ESPECIALLY USEFUL WHEN IT IS DESIRED TO LIQUEFY THICK, TENACIOUS SPUTUM. IN THE BODY, SODIUM CITRATE IS OXIDIZED TO BICARBONATE & EXCRETED IN THE URINE; THUS, WHEN GIVEN ORALLY IT IS USEFUL IN ACIDOSIS & TO OVERCOME EXCESSIVE URINARY ACIDITY.|SODIUM CITRATE ALSO HAS A DIURETIC...ACTION.|SODIUM CITRATE ALSO INCREASES THE URINARY EXCRETION OF CALCIUM. THEREFORE, IT HAS BEEN EMPLOYED IN HYPERCALCEMIA & TO FACILITATE ELIMINATION OF LEAD IN POISONING DUE TO THE LATTER AGENT. /SRP: FORMER USE/|MEDICATION (VET): ANTICOAGULANT FOR COLLECTION OF BLOOD /SRP: FORMER USE/

WHEN GIVEN IN EXCESS AMT SODIUM CITRATE MAY PRODUCE ALKALOSIS & MAY CAUSE TETANY OR DEPRESS THE HEART BY DECREASING THE IONIZED CALCIUM LEVEL OF THE BLOOD.

Citrate prevents activation of the clotting cascade by chelating calcium ions. Citrate neutralizes acid in the stomach and urine, raising the pH.

Agents that prevent BLOOD CLOTTING. (See all compounds classified as Anticoagulants.)|Substances capable of inhibiting, retarding or arresting the process of fermentation, acidification or other deterioration of foods. (See all compounds classified as Food Preservatives.)|A chemical system that functions to control the levels of specific ions in solution. When the level of hydrogen ion in solution is controlled the system is called a pH buffer. (See all compounds classified as Buffers.)

Tmax of 98-130min.|Largely eliminated through hepatic metabolism with very little cleared by the kidneys.|19-39L.|Total clearance of 313-1107mL/min.|IN THE BODY, SODIUM CITRATE IS OXIDIZED TO BICARBONATE & EXCRETED IN THE URINE...

Citrate is metabolized to bicarbonate in the liver and plays a role as an intermediate in the citric acid cycle.|IN THE BODY, SODIUM CITRATE IS OXIDIZED TO BICARBONATE...

18-54 min

Citrate chelates free calcium ions preventing them from forming a complex with tissue factor and coagulation factor VIIa to promote the activation of coagulation factor X. This inhibits the extrinsic initiation of the coagulation cascade. Citrate may also exert an anticoagulant effect via a so far unknown mechanism as restoration of calcium concentration does not fully reverse the effect of citrate. Citrate is a weak base and so reacts with hydrochloric acid in the stomach to raise the pH. It it further metabolized to bicarbonate which then acts as a systemic alkalizing agent, raising the pH of the blood and urine. It also acts as a diuretic and increases the urinary excretion of calcium.

Fresh air, rest.

Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

anhydrous sodium citrate

The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Cough. Sore throat.

Redness.

SODIUM CITRATE IS AN INGREDIENT IN ANTICOAGULANT CITRATE DEXTROSE SOLUTION USP; ANTICOAGULANT CITRATE PHOSPHATE DEXTROSE SOLUTION USP; & SODIUM CITRATE & CITRIC ACID SOLUTION USP.|Grades: highest purity, medicinal; pure, commercial, CP; USP; FCC. /Dihydrate/

All other chemical product and preparation manufacturing|1,2,3-Propanetricarboxylic acid, 2-hydroxy-, sodium salt (1:3): ACTIVE

MODIFICATION OF USP METHOD FOR ASSAY OF SYSTEMIC ALKALIZER SOLN CONTAINING MIXT OF CITRATE & CITRIC ACID IS PRESENTED. IT INVOLVES TWO TITRATIONS & ION-EXCHANGE CHROMATOGRAPHY.

EPA Safer Chemical Functional Use Classes -> Chelating Agents;Preservatives and Antioxidants;Processing Aids and Additives|Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern|Food additives|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Food Additives -> ACIDITY_REGULATOR; SEQUESTRANT; STABILIZER; -> JECFA Functional Classes|Cosmetics -> Buffering; Chelating

Food Additives -> ACIDITY_REGULATOR; SEQUESTRANT; STABILIZER;