Propanedioic acid, 2,2-dibutyl-, 1,3-diethyl ester

colourless liquid

Under the protection of nitrogen, the 100g c diethyl malonate, 300 ml anhydrous ethanol into 1000 ml three port in round bottomed flask, under room temperature, adding 40.5g sodium methoxide, then, slowly adding 102.8g bromo n-butane, after adding heating reflux, the reaction 3h; to cool down to room temperature, then adding 40.5g sodium methoxide, then, slowly adding 102.8g bromo-butane, heating reflux reaction 3h. Cooling to room temperature, removing the solvent, by adding 1 mol/L sulfuric acid aqueous solution in the pH value and system to 7 the left and the right, washing the organic phase, is distilled under reduced pressure to obtain the dibutyl c diethyl malonate, 154g (yield 90.6percent).

Molecular Weight:272.38
XLogP3:4.7
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:12
Exact Mass:272.19875937
Monoisotopic Mass:272.19875937
Topological Polar Surface Area:52.6
Heavy Atom Count:19
Complexity:245
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes