 Home > Encyclopedia > Fluphenazine decanoate

Fluphenazine decanoate

Fluphenazine decanoate structure

CAS No:
5002-47-1
Formula:
C32H44F3N3O2S
Chemical Name:
Fluphenazine decanoate
Synonyms:
Decanoic acid,2-[4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-piperazinyl]ethyl ester;Decanoic acid,2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]-1-piperazinyl]ethyl ester;1-Piperazineethanol,4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]-,decanoate (ester);SQ 10733;Fluphenazine decanoate;Fluorophenazine decanoate;Dapotum D;Lyogen;Modecate;Flufenazine decanoate;Prolixin decanoate;Moditen depot;QD 10733;Depot;NSC 169510;2-(4-(3-(2-(Trifluoromethyl)-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethyl decanoate
Categories:
Analytical Chemistry > Standard

Description

Fluphenazine decanoate is a long-acting phenothiazine neuroleptic that used to treat schizophrenia. Fluphenazine decanoate is also a high and continuous dopamine D2 receptor blocker[1][2][3].

Fluphenazine decanoate is the prodrug of fluphenazine, an antipsychotic drug used for the symptomatic management of psychosis in patients with schizophrenia. It has a role as a phenothiazine antipsychotic drug, a prodrug and a dopaminergic antagonist. It is a member of phenothiazines, a decanoate ester, an organofluorine compound and a N-alkylpiperazine. It derives from a fluphenazine.|Fluphenazine Decanoate is the decanoate salt form of fluphenazine, a phenothiazine with antipsychotic activity. Fluphenazine decanoate exerts its actions by blocking postsynaptic dopamine D2 receptors in the limbic, cortical system and basal ganglia. This prevents the actions of dopamine, thereby reducing the hallucinations and delusions that are associated with schizophrenia.

Fluphenazine decanoate Basic Attributes

Molecular Weight：

591.77

Exact Mass：

591.77

EC Number：

225-672-4

UNII：

FMU62K1L3C

NSC Number：

169510

DSSTox ID：

DTXSID7023069

NCI Thesaurus Code：

C47996

HScode：

3003909090

Characteristics

PSA：

61.32000

XLogP3：

7.94050

Density：

1.149 g/cm3

Melting Point：

30-32 °C

Boiling Point：

658.1ºCat 760 mmHg

Flash Point：

351.8ºC

Refractive Index：

1.537

Water Solubility：

Practically insoluble in water, very soluble in ethanol and in methylene chloride, freely soluble in methanol.

Safety Information

Packing level：

Hazard category：

6.1(a)

Transport codes：

3249

RTECS Number：

HE0525000

GHS Classification：

|Danger|H300 (39.29%): Fatal if swallowed [Danger Acute toxicity, oral]|P201, P202, P261, P264, P270, P271, P272, P280, P281, P285, P301+P310, P301+P312, P302+P352, P304+P312, P304+P340, P304+P341, P308+P313, P312, P321, P322, P330, P332+P313, P333+P313, P342+P311, P362, P363, P405, and P501|Aggregated GHS information provided by 28 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)

MeSH Entry Terms：

fluphenazine decanoate

Fluphenazine decanoate Use and Manufacturing

Uses

Fluphenazine Decanoate is used in psychotropic drug treatments like those relating to schizophrenia. Antipsychotic.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:591.8
XLogP3:9
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:16
Exact Mass:591.31063331
Monoisotopic Mass:591.31063331
Topological Polar Surface Area:61.3
Heavy Atom Count:41
Complexity:765
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product is a long-acting ester compound of fluphenazine. Its antipsychotic effect is mainly related to its blocking of dopamine receptors (DA2) in the brain, inhibiting the ascending activation system of the reticular formation and having a sedative effect. Its antiemetic and blood pressure-lowering effects are weaker.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Fluphenazine Deca Injection
Specifications	1ml:25mg

Fluphenazine Deca Injection
Ingredients	Fluphenazine
Indication	1. When this product is used in combination with ethanol or other central nervous system depressants, the central nervous system depressant effect is enhanced. 2. When this product is used in combination with antihypertensive drugs, it is easy to cause the risk of postural hypotension. 3. When this product is used in combination with sultopride, there is a risk of ventricular arrhythmia, which may cause torsades de pointes in severe cases. 4. When this product is used in combination with atropine drugs, the adverse reactions are enhanced. 5. When this product is used in combination with lithium salts, it can cause loss of consciousness
Specifications	1ml: 25mg

Fluphenazine Deca Injection
Ingredients	The main ingredient of this product is fluphenazine decafluoroacetate, and its chemical name is: 4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-piperazine ethanol decanoate
Indication	1. When this product is used in combination with ethanol or other central nervous system depressants, the central depressant effect is enhanced. 2. When this product is used in combination with antihypertensive drugs, it is easy to cause the risk of postural hypotension. 3. When this product is used in combination with sultopride, there is a risk of ventricular arrhythmia, which may cause torsades de pointes in severe cases. 4. When this product is used in combination with atropine drugs, the adverse reactions are enhanced. 5. When this product is used in combination with lithium salts, it can cause loss of consciousness.
Specifications	1 ml: 25 mg

See More Related Drugs

Registered Holders

FINE CHEMICALS CORP PTY LTD

United States
Active
GLAND PHARMA LTD

India
Active
TRIFARMA SPA

Brazil
Active

See More Registered Holders