1,3,4,6,7,11b-Hexahydro-2H-pyrazino[2,1-a]isoquinoline

2-(l, 3, 4, 6, 7, llbηexahydro-pyrazino[2, l-a]isoquinolin-2-yl)-3'methyl- 6-pyridin-4-yl-3H-pyrimidin-4-one (Compound No.Bl09); 1, 3, 4.6, 7, llb-Hexahvdro-2H-pvrazino[2, l-alisoquinoline; 1, 2, 3, 6, 7, llb-Hexahydro-pyrazino[2, l-a]isoquinolin'4-one (3.03 g, 15.0 mmol) was added to a solution of lithium aluminum hydride (1.14 g, 30.0 mmol) in tetrahydrofuran (63 ml) and the mixture was refluxed for 6 hours. Water (1.2 ml), 15percent aqueous sodium hydroxide (1.2 ml) and water (3.2 ml) were added sequentially to the ice'cooled solution, and filtration of the precipitate and removal of the solvent under reduced pressure afforded 1, 3, 4, 6, 7, llb-hexahydro-2H-pyrazino[2, l-a] isoquinoline (2.77 g, 98percent).Compound 1 (3.03 g, 15 mmol) was added to a solution of lithium aluminum hydride (1.14 g, 30 mmol) in tetrahydrofuran (63 mL) and the mixture was refluxed for 10 h After cooled to 0 °C, the reaction was quenched with aqueous sodium hydroxide (15percent, 1.2 mL), and the precipitate was filtrated. The organic phases were then processed in the usual way and chromatographed (10:1 CH2-(l, 3, 4, 6, 7, llbηexahydro-pyrazino[2, l-a]isoquinolin-2-yl)-3'methyl- 6-pyridin-4-yl-3H-pyrimidin-4-one (Compound No.Bl09); 1, 3, 4.6, 7, llb-Hexahvdro-2H-pvrazino[2, l-alisoquinoline; 1, 2, 3, 6, 7, llb-Hexahydro-pyrazino[2, l-a]isoquinolin'4-one (3.03 g, 15.0 mmol) was added to a solution of lithium aluminum hydride (1.14 g, 30.0 mmol) in tetrahydrofuran (63 ml) and the mixture was refluxed for 6 hours. Water (1.2 ml), 15percent aqueous sodium hydroxide (1.2 ml) and water (3.2 ml) were added sequentially to the ice'cooled solution, and filtration of the precipitate and removal of the solvent under reduced pressure afforded 1, 3, 4, 6, 7, llb-hexahydro-2H-pyrazino[2, l-a] isoquinoline (2.77 g, 98percent).Compound 1 (3.03 g, 15 mmol) was added to a solution of lithium aluminum hydride (1.14 g, 30 mmol) in tetrahydrofuran (63 mL) and the mixture was refluxed for 10 h After cooled to 0 °C, the reaction was quenched with aqueous sodium hydroxide (15percent, 1.2 mL), and the precipitate was filtrated. The organic phases were then processed in the usual way and chromatographed (10:1 CH

Molecular Weight:188.27
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:188.131348519
Monoisotopic Mass:188.131348519
Topological Polar Surface Area:15.3
Heavy Atom Count:14
Complexity:205
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes