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Buformin

Buformin structure

CAS No:
692-13-7
Formula:
C6H15N5
Chemical Name:
Buformin
Synonyms:
Imidodicarbonimidic diamide,N-butyl-;Biguanide,1-butyl-;N-Butylimidodicarbonimidic diamide;W 37;H 224;Buformin;Buformine;N1-Butylbiguanide;DBV;1-Butylbiguanide;Butylbiguanide;Butformin;Butyldiguanide;Glybigid;Dibetos B
Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System

Description

Buformin is a member of the class of biguanides that is biguanide substituted by a butyl group at position 1. It is an antidiabetic drug with potential antitumor effect. It has a role as a hypoglycemic agent, a geroprotector, a radiosensitizing agent, an antineoplastic agent and an antiviral agent. It derives from a biguanide.|Buformin is an anti-diabetic drug of the biguanide class, chemically related to metformin and phenformin. It was withdrawn from the market in most countries due to a high risk of causing lactic acidosis.|Buformin is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity. Buformin is not metabolized and is excreted in the urine. This agent has been withdrawn from the market due to its elevated risk of lactic acidosis.|An oral hypoglycemic agent that inhibits gluconeogenesis, increases glycolysis, and decreases glucose oxidation.

Buformin Basic Attributes

Molecular Weight：

157.2168

Exact Mass：

157.22

EC Number：

211-726-4

UNII：

W2115E9C7B

DSSTox ID：

DTXSID6046420

NCI Thesaurus Code：

C95328

ATC Code：

A - Alimentary tract and metabolism

Characteristics

PSA：

103

XLogP3：

-1.2

Density：

1.22g/cm3

Melting Point：

174-176 °C

Boiling Point：

322.7ºC at 760 mmHg

Flash Point：

148.9ºC

Refractive Index：

1.568

Toxicity：

Oral-Mouse LD50: 300 mg/kg; Abdominal cavity-mouse LD50: 140 mg/kg

Flammability characteristics：

Thermal decomposition to emit toxic nitrogen oxide fumes

Safety Information

Storage features：

Warehouse ventilated, low temperature and dry; stored separately from food raw materials

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH：

Substances which lower blood glucose levels. (See all compounds classified as Hypoglycemic Agents.)

MeSH Entry Terms：

1 Butylbiguanide

Buformin Use and Manufacturing

Buformin, clinically used for diabetes mellitus, is known to improve resistance to insulin in patients. It suppresses the expression of glyceraldehyde 3-phosphate dehydrogenase

Computed Properties

Molecular Weight:157.22
XLogP3:-0.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:4
Exact Mass:157.13274550
Monoisotopic Mass:157.13274550
Topological Polar Surface Area:103
Heavy Atom Count:11
Complexity:156
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes